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Case-control study for lifestyle related risk factors of early spontaneous abortions

早期自然流产生活方式相关危险因素的病例对照研究

基本信息

批准号：
21890128
负责人：
BABA Sachiko
金额：
$ 1.51万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Research Activity Start-up
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2010
项目状态：
已结题

项目摘要

In this matched case-control study, we investigated the associations of reproductive and lifestyle characteristics of women with early spontaneous abortion <12 weeks of gestation.Information was collected through medical records for 430 cases of early spontaneous abortion and 860 controls of term delivery. Two controls were individual-matched to one case according to maternal age (+/-3 years) and calendar year of events (either early spontaneous abortion or delivery). Multivariable conditional odds ratios (ORs) and 95% confidence interval (CI) were calculated with conditional logistic-regression.The risk of early spontaneous abortions was higher for women with a past history of early spontaneous abortions. Maternal smoking and employment also influence risk. Our finding suggests that for Japanese women, smoking and working may be important public health issue targets for the prevention of early spontaneous abortions.

本研究采用配对病例对照研究方法，通过收集430例孕12周以下早期自然流产妇女和860例足月分娩对照妇女的病历资料，探讨孕12周以下早期自然流产妇女的生育和生活方式特征。根据母亲年龄（+/-3岁）和事件发生的日历年（早期自然流产或分娩），将两个对照组与一个病例进行个体匹配。多因素条件优势比（OR）和95%可信区间（CI）采用条件Logistic回归分析，有早期自然流产史的妇女早期自然流产的风险更高。母亲吸烟和就业也会影响风险。我们的研究结果表明，对于日本妇女来说，吸烟和工作可能是预防早期自然流产的重要公共卫生问题目标。