Development of a novel method of promoting alveolar bone formation by controlling the expression of BMP antagonist.

本研究的目的是鉴定BMP-2诱导成骨分化过程中表达的BMP拮抗剂，并建立一种通过调控这些拮抗剂的表达来促进牙槽骨形成的新方法。在这项研究中，我证明敲低SOST RNA干扰在体外导致成骨标志物碱性磷酸酶的表达和细胞外矿物质的沉积显着增加，响应成骨刺激。

The purpose of this study is to identify the BMP antagonists which expressed during osteogenic differentiation induced by BMP-2 and develop a novel method for promoting alveolar bone formation by controlling the expression of those antagonists. In this study, I demonstrate knockdown of SOST by RNA interference in vitro resulted in a significant increase in the expression of the osteogenic marker alkaline phosphatase and the deposition of extracellular mineral, in response to osteogenic stimulation.