Development of a novel method of promoting alveolar bone formation by controlling the expression of BMP antagonist.

开发一种通过控制 BMP 拮抗剂的表达来促进牙槽骨形成的新方法。

• 批准号: 21890149
• 负责人: FUJISAWA Takuo
• 金额: $ 2万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890149/
• 关键词: 質細胞; BMP; BMPアンタゴニスト; siRNA; 骨髄由来間質細胞

The purpose of this study is to identify the BMP antagonists which expressed during osteogenic differentiation induced by BMP-2 and develop a novel method for promoting alveolar bone formation by controlling the expression of those antagonists. In this study, I demonstrate knockdown of SOST by RNA interference in vitro resulted in a significant increase in the expression of the osteogenic marker alkaline phosphatase and the deposition of extracellular mineral, in response to osteogenic stimulation.

本研究的目的是鉴定BMP-2诱导成骨分化过程中表达的BMP拮抗剂，并建立一种通过调控这些拮抗剂的表达来促进牙槽骨形成的新方法。在这项研究中，我证明敲低SOST RNA干扰在体外导致成骨标志物碱性磷酸酶的表达和细胞外矿物质的沉积显着增加，响应成骨刺激。

项目成果

Suppression of BMP-2-induced osteogenic differentiation of hBMSCs by TNF-alpha.

TNF-α 抑制 BMP-2 诱导的 hBMSC 成骨分化。

• 发表时间: 2010
• 作者: Matsuo N;Shiraha H;Fujikawa T;Takaoka N;Ueda N;Tanaka S;Nishina S;Nakanishi Y;Uemura M;Takaki A;Nakamura S;Kobayashi Y;Nouso K;Yagi T;Yamamoto K.;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;能祖一裕;Fujisawa T
• 通讯作者: Fujisawa T