Identification of flavonoids-binding proteins, and basic research of cancer prevention based on molecular mechanisms

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A number of flavonoids in food are believed to have cancer chemopreventive activity. This research identified flavonoids-binding proteins by utilizing nano-magnetic beads and MALDI-TOF MS. Moreover, it was clarified that apigenin-binding protein 1 (ABP1) regulated the G2 phase of the cell cycle, and apigenin inhibited the proliferation of HT-29 cells by inhibiting ABP1. This achievement is the first evidence that explains thecancer chemopreventive activity of flavonoids from flavonoids-binding proteins.