Identification of the cancer preventive targets useful foractivating the tumor suppressive gene p21

P53是肿瘤抑制基因之一，通过上调p21来抑制肿瘤的发生。到目前为止，我们澄清了食物中的一些化合物可以诱导p53突变的癌细胞中的p21。在本研究中，我们鉴定了与这些化合物结合的蛋白质，并检测了结合蛋白是否与p21的表达有关。遗憾的是，这些蛋白与p21的表达之间没有关系。然而，我们发现其中一种结合蛋白调节癌细胞的生长和Akt，Akt在癌细胞中经常被激活。

p53, one of the tumor suppressor genes, inhibits carcinogenesis by upregulating p21. Until now, we clarified that a few of compounds in food induced p21 in p53-mutated cancer cells. In the present study, we identified the proteins which bound to these compounds and examined whether the binding proteins were related to p21 expression. Unfortunately, there was not the relation between these proteins and p21 expression. However, we found that one of the binding proteins regulated the growth of cancer cells and Akt, which is frequently activated in cancer cells.