Identification of the cancer preventive targets useful foractivating the tumor suppressive gene p21

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p53, one of the tumor suppressor genes, inhibits carcinogenesis by upregulating p21. Until now, we clarified that a few of compounds in food induced p21 in p53-mutated cancer cells. In the present study, we identified the proteins which bound to these compounds and examined whether the binding proteins were related to p21 expression. Unfortunately, there was not the relation between these proteins and p21 expression. However, we found that one of the binding proteins regulated the growth of cancer cells and Akt, which is frequently activated in cancer cells.