Simulation and analysis of stem cell-carcinogenesis induced by chemical carcinogens using murine embryonic stem cell

在mES细胞和MEF中检测到Cyp 1a 1和Cyp 1b 1。Cyp 1b 1在MEF中的表达水平是mES细胞的14倍。3-甲基胆蒽（3-MC）处理诱导Cyp 1a 1和Cyp 1b 1在两种细胞中的表达以剂量依赖性的方式。尤其是Cyp 1a 1在MEF中被显著诱导。这些结果表明，疏水性异生物质倾向于集中在未分化的细胞，如组织干细胞，但需要进一步的研究。

Cyp1a1 and Cyp1b1 were detected in mES cell and MEF. The extent of Cyp1b1 expression was 14 times higher in MEF as compared with mES cell. 3-Methylcholanthrene (3-MC) treatment was induced Cyp1a1 and Cyp1b1 expressions in both cells in a dose-dependent manner. Especially, Cyp1a1 was induced significantly in MEF. These results suggest that hydrophobic xenobiotics tend to be concentrated in undifferentiated cells such as tissue stem cells, although further study is needed.