Development of novel DDS carriers incorporating water-soluble drug and potential for click release

药物传递系统（DDS）通过化学修饰药物载体来提高癌症治疗的疗效具有巨大的潜力。然而，有限的DDS策略已报道与水溶性药物，到目前为止还没有候选达到临床应用。我们开发了一种新的方法来制备水溶性药物吉西他滨的DDS载体，并研究了该载体在DDS应用中的潜力。内容如下：i)吉西他滨合并DDS载体的制备。ii)药物释放行为：ph响应iii)载体的体外活性。

Drug delivery system(DDS) have enormous potential to improve the efficacy of cancer treatment by chemical modification of drug vehicles. However, limited DDS strategies have been reported with water-soluble drugs, and so far no candidate to reach up to the clinical use. We have developed novel strategy to prepare DDS carrier incorporating water-soluble drug : gemcitabine, and study the potential of this carrier for DDS usage. The contents were the followings.i) Preparation of gemcitabine incorporated DDS carrier.ii) Drug release behavior : pH-responsiveiii) in vitro activity of carrier.