Regulatory mechanisms for the proliferation and invasion under oxidative stress via modulation of membranous glycolipids.

通过调节膜糖脂来调节氧化应激下增殖和侵袭的调节机制。

• 批准号: 20580369
• 负责人: MIURA Yutaka
• 金额: $ 3.08万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20580369/
• 关键词: 癌細胞浸潤; 酸化ストレス; 細胞膜糖脂質; ガングリオシド; 癌細胞増殖; 糖脂質; 細胞膜; 癌転移

The regulatory mechanisms for the protentiation of mouse melanoma cell invasion under hypoxic condition were investigated. The increase in membranous ganglioside GM3 contents and the modulation of proteins-glycolipids complex in cell membrane were proved to be deeply involved in this phenomenon. This result indicates novel mechanisms for cancer aggravation under hypoxia.

探讨了低氧条件下保护小鼠黑色素瘤细胞侵袭的调控机制。细胞膜神经节苷脂GM3含量的增加和细胞膜蛋白质-糖脂复合体的调节被证明与此现象密切相关。这一结果表明了在低氧条件下癌症恶化的新机制。

项目成果

Parvulin (Par14), a peptidyl prolyl cis-trans isomerase, is a novel rRNA-processing factor evolved in the metazoan lineage.

Parvulin (Par14) 是一种肽基脯氨酰顺反异构酶，是后生动物谱系中进化的一种新型 rRNA 加工因子。

• 发表时间: 2009
• 期刊: Mol.Cell.Proteomics vol.8
• 作者: Fujiyama-Nakamura S;Yoshikawa H;Homma K;Hayano T;Tsujimura-Takahashi T;Izumikawa K;Ishikawa H;Miyazawa N;Yanagida M;Miura Y;Shinkawa T;Yamauchi Y;Isobe T;Takahashi N
• 通讯作者: Takahashi N

Parvulin (Par14), a Peptidyl-Prolyl cis-trans Isomerase, Is a Novel rRNA Processing Factor That Evolved in the Metazoan Lineage

• DOI: 10.1074/mcp.m900147-mcp200
• 发表时间: 2009-07-01
• 期刊: MOLECULAR & CELLULAR PROTEOMICS
• 影响因子: 7
• 作者: Fujiyama-Nakamura, Sally;Yoshikawa, Harunori;Takahashi, Nobuhiro
• 通讯作者: Takahashi, Nobuhiro

Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells.

• DOI: 10.3164/jcbn.10-119
• 发表时间: 2011-05
• 期刊: Journal of clinical biochemistry and nutrition
• 影响因子: 2.4
• 作者: Minakawa M;Kawano A;Miura Y;Yagasaki K
• 通讯作者: Yagasaki K

Yagasaki K Effects of simultaneous dietary fish oil ingestion and sulfur amino acid supplementation on the lipid metabolism in hepatoma-bearing rats with hyperlipidemia.

Yagasaki K同时膳食鱼油摄入和硫氨基酸补充对患有高脂血症的肝癌大鼠脂质代谢的影响。

• 发表时间: 2010
• 期刊: J Nutr.Sci.Vitaminol. 56
• 作者: Kawasaki M;Miura Y;Funabiki R
• 通讯作者: Funabiki R

Regulation of mouse melanoma invasion by membranous ganglioside GM3.

膜神经节苷脂 GM3 对小鼠黑色素瘤侵袭的调节。

• 发表时间: 2010
• 作者: Yosuke Oikawa;Manami Miyake;Kazumi Yagasaki;Yagasaki Miura
• 通讯作者: Yagasaki Miura