Regulatory mechanisms for the proliferation and invasion under oxidative stress via modulation of membranous glycolipids.
Regulatory mechanisms for the proliferation and invasion under oxidative stress via modulation of membranous glycolipids.
批准号:
20580369
负责人:
MIURA Yutaka
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
探讨了低氧条件下促进小鼠黑色素瘤细胞侵袭的调控机制。细胞膜神经节苷脂GM 3含量的增加和细胞膜蛋白-糖脂复合物的调节与这一现象密切相关。这一结果表明了缺氧条件下癌症恶化的新机制。
英文摘要
The regulatory mechanisms for the protentiation of mouse melanoma cell invasion under hypoxic condition were investigated. The increase in membranous ganglioside GM3 contents and the modulation of proteins-glycolipids complex in cell membrane were proved to be deeply involved in this phenomenon. This result indicates novel mechanisms for cancer aggravation under hypoxia.
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Parvulin (Par14), a peptidyl prolyl cis-trans isomerase, is a novel rRNA-processing factor evolved in the metazoan lineage.
Parvulin (Par14) 是一种肽基脯氨酰顺反异构酶,是后生动物谱系中进化的一种新型 rRNA 加工因子。
DOI:
--
发表时间:
2009
期刊:
Mol.Cell.Proteomics vol.8
影响因子:
--
作者:
[Fujiyama-Nakamura S, Yoshikawa H, Homma K, Hayano T, Tsujimura-Takahashi T, Izumikawa K, Ishikawa H, Miyazawa N, Yanagida M, Miura Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N]
通讯作者:
Takahashi N
DOI:
10.1074/mcp.m900147-mcp200
发表时间:
2009-07-01
期刊:
MOLECULAR & CELLULAR PROTEOMICS
影响因子:
7
作者:
[Fujiyama-Nakamura, Sally, Yoshikawa, Harunori, Takahashi, Nobuhiro]
通讯作者:
Takahashi, Nobuhiro
DOI:
10.3164/jcbn.10-119
发表时间:
2011-05
期刊:
Journal of clinical biochemistry and nutrition
影响因子:
2.4
作者:
[Minakawa M, Kawano A, Miura Y, Yagasaki K]
通讯作者:
Yagasaki K
Yagasaki K Effects of simultaneous dietary fish oil ingestion and sulfur amino acid supplementation on the lipid metabolism in hepatoma-bearing rats with hyperlipidemia.
Yagasaki K同时膳食鱼油摄入和硫氨基酸补充对患有高脂血症的肝癌大鼠脂质代谢的影响。
DOI:
--
发表时间:
2010
期刊:
J Nutr.Sci.Vitaminol. 56
影响因子:
--
作者:
[Kawasaki M, Miura Y, Funabiki R]
通讯作者:
Funabiki R
Regulation of mouse melanoma invasion by membranous ganglioside GM3.
膜神经节苷脂 GM3 对小鼠黑色素瘤侵袭的调节。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yosuke Oikawa, Manami Miyake, Kazumi Yagasaki, Yagasaki Miura]
通讯作者:
Yagasaki Miura
共 19 条
Novel mechanisms for unabosorbable food factors with anti-life style-related deseases activities
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批准号:26500003
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2014
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负责人:MIURA Yutaka
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依托单位:
Ligand-Linked Polymeric Micelles for Targeted Delivery of Platinum Anti-Cancer Drug into Malignant Tumor
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批准号:24659584
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:MIURA Yutaka
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依托单位:
Novel nutritional function of sphingolipids via secreted exosomes
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批准号:23617005
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:MIURA Yutaka
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依托单位:
Development of novel DDS carriers incorporating water-soluble drug and potential for click release
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批准号:22800013
-
项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$1.95万
-
财政年份:2010
-
负责人:MIURA Yutaka
-
依托单位:
Involvement of membrane microdomains in oxidative stress-induced invasion of hepatoma cells
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批准号:17580296
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.43万
-
财政年份:2005
-
负责人:MIURA Yutaka
-
依托单位:
海外基金