Characterization and in vivo evaluation of nano-sized polyion complex vesicles with varying elasticity

我们先前已经证明了通过一对带相反电荷的聚合物的自组装在自发形成的亚微米尺寸的聚离子复合物囊泡（Nano-PIC囊泡）中的有趣特性，由此通过缩合试剂交联PIC膜可以控制许多特性，包括改善血液循环和生物分布。在这段时间里，我们成功地表征和在体内评价纳米PIC与各种交联比和大小。

We have previously demonstrated interesting properties in spontaneously formed submicron-sized polyion complex vesicles(Nano-PICsomes) via the self-assembly of a pair of oppositely charged polymers, whereby cross-linking of the PIC membrane by a condensation reagent can control many properties, including improvement of blood circulation and biodistribution. In this time, we succeeded in the characterization and in vivo evaluation of Nano-PICsomes with various cross-linking ratios and sizes.