Pathological roles of iron metabolism in rat models of myelin disease and hepatic fibrosis

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We examined changes in iron metabolism in rat models of CNS myelin and liver diseases. It was found that abnormal iron accumulation and oxidative stress are involved in the pathogenesis of the demyelinating dmy mutant rat, but not in the hypomyelinating mv rat. Rats with acute hepatic injury, induced by a single injection of thioacetamide, develop transient iron accumulation in the liver, which is recovered by upregulation of iron regulatory factors such as hepcidin, a central regulator of systemic iron homeostasis. Hepatic iron overload is induced in rats with hepatic fibrosis induced by repeated injection of thioacetamide.