Pathological roles of iron metabolism in rat models of myelin disease and hepatic fibrosis

铁代谢在大鼠髓鞘质疾病和肝纤维化模型中的病理作用

• 批准号: 22880029
• 负责人: IZAWA Takeshi
• 金额: $ 1.98万
• 依托单位: Osaka Prefecture University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22880029/
• 关键词: 鉄代謝; 鉄調節因子; 難治疾患; 肝線維化; ミエリン疾患

We examined changes in iron metabolism in rat models of CNS myelin and liver diseases. It was found that abnormal iron accumulation and oxidative stress are involved in the pathogenesis of the demyelinating dmy mutant rat, but not in the hypomyelinating mv rat. Rats with acute hepatic injury, induced by a single injection of thioacetamide, develop transient iron accumulation in the liver, which is recovered by upregulation of iron regulatory factors such as hepcidin, a central regulator of systemic iron homeostasis. Hepatic iron overload is induced in rats with hepatic fibrosis induced by repeated injection of thioacetamide.

我们检查了中枢神经系统髓磷脂和肝脏疾病大鼠模型中铁代谢的变化。研究发现，异常的铁积累和氧化应激参与了脱髓鞘dmy突变大鼠的发病机制，但在低髓鞘mv大鼠中则不参与。单次注射硫代乙酰胺引起急性肝损伤的大鼠会在肝脏中出现短暂的铁积累，这种积累可通过铁调素（全身铁稳态的中央调节剂）等铁调节因子的上调来恢复。反复注射硫代乙酰胺诱导肝纤维化大鼠出现肝铁超负荷。

项目成果

Encapsulating Peritoneal Sclerosis Associated with Abnormal Liver Development in a Young Dog

• DOI: 10.1292/jvms.10-0503
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Izawa, Takeshi;Murai, Fumi;Kuwamura, Mitsuru
• 通讯作者: Kuwamura, Mitsuru

Thioacetamide誘発ラット急性肝障害における鉄調節因子群の発現プロファイリング

硫代乙酰胺诱导的大鼠急性肝损伤中铁调节因子的表达谱

• 发表时间: 2012
• 作者: Yumiko Suzuki;Hiroshi Okamoto;Makoto Takahashi;Takashi Kataoka;Youichi Shibata;大塚剛司,都合勇希,友永省三,長澤麻央,後藤真梨子,古瀬充宏,安尾しのぶ;井澤武史
• 通讯作者: 井澤武史