Basic Study of functionality and cell differentiation of decidual macrophages targeting the development of novel clinical approach for the prediction and the therapy of preterm delivery.

蜕膜巨噬细胞的功能和细胞分化的基础研究，旨在开发用于预测和治疗早产的新临床方法。

• 批准号: 22890045
• 负责人: NAGAMATSU Takeshi
• 金额: $ 1.87万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890045/
• 关键词: 早産; マクロファージ; 脱落膜; 免疫; 妊娠; 共刺激分子

This study aimed to investigate the relevance of decidual macrophages in the pathology of preterm delivery. We clarified that decidual macrophages have unique immunological property that promotes maternal tolerance to fetal antigen mediated by humoral factors and direct cell-to-cell interaction. Our finding proposed that this anti-inflammatory property might act as a negative factor upon preterm delivery, leading to the progression of intrauterine infection. In the analysis using mouse model, functional switching of macrophages to pro-inflammatory phenotype occurs upon intrauterine infection. The suppression of this phenotypical shift using anti-inflammatory substance can be a new strategy for the treatment of preterm delivery.

本研究旨在探讨蜕膜巨噬细胞在早产病理中的相关性。我们阐明了蜕膜巨噬细胞具有独特的免疫学特性，通过体液因子和直接的细胞间相互作用促进母体对胎儿抗原的耐受。我们的研究结果表明，这种抗炎特性可能作为一个负面因素，早产后，导致宫内感染的进展。在使用小鼠模型的分析中，巨噬细胞向促炎表型的功能转换发生在宫内感染后。使用抗炎物质抑制这种表型转变可能是治疗早产的新策略。

项目成果

The regulation of T-cell activity by decidual cells via PD-1:B7-H1/-DC

蜕膜细胞通过 PD-1:B7-H1/-DC 对 T 细胞活性的调节

• 发表时间: 2011
• 作者: Sayama S;Nagamatsu T
• 通讯作者: Nagamatsu T

The regulation of T-cell activity by decidual cells via PD-1 : B7-H1/-DC interaction

蜕膜细胞通过 PD-1 : B7-H1/-DC 相互作用调节 T 细胞活性

• 发表时间: 2011
• 作者: Sayama S;Nagamatsu T;Yamashita A;Kojima S;Tomio K;Kawana K;Fujii T;Kouzuma S;Taketani Y
• 通讯作者: Taketani Y

Does the classical M1/M2 dichotomy reflect the functional phenotypes of human decidual macrophages

经典的M1/M2二分法是否反映了人类蜕膜巨噬细胞的功能表型

• DOI: 10.1586/eog.11.34
• 发表时间: 2011
• 期刊: Expert Review of Obstetrics & Gynecology
• 作者: Danny J Schust;Takeshi Nagamatsu
• 通讯作者: Takeshi Nagamatsu

Decidual stromal cells suppress T cell activation via IDO and costimulatory pathways

蜕膜基质细胞通过 IDO 和共刺激途径抑制 T 细胞活化

• 发表时间: 2010
• 作者: Nagamatsu T;Fujii T;Sayama S;Kawana K;Hyodo H;Yamashita T;Schust DJ;Kozuma S;Taketani Y
• 通讯作者: Taketani Y

A Possible Coagulation-Independent Mechanism for Pregnancy Loss Invo lving β(2) glycoprotein 1-Dependent Antiphospholipid Antibodies and CD1d

涉及 β(2) 糖蛋白 1 依赖性抗磷脂抗体和 CD1d 的可能的不依赖凝血机制的妊娠流产

• 发表时间: 2012
• 期刊: American Journal of Reproductive Immunology
• 影响因子: 3.6
• 作者: Miyagaki T;Sugaya M;Murakami T;Asano Y;Tada Y;Kadono T;Okochi H;Tamaki K;Sato S;Yuki Iwasasa
• 通讯作者: Yuki Iwasasa