The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

生长因子介导人牙龈上皮细胞细胞粘附机制的分子生物学分析

• 批准号: 22890119
• 负责人: YAMASHIRO Keisuke
• 金额: $ 1.91万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890119/
• 关键词: 歯肉上皮細胞; TGF-β; インテグリン; 細胞外基質; Smad2; Aggregatibacter actinomycetemcomitans; 細胞接着因子; 細胞外マトリックス; Aggregatibacter ac; フィブロネクチン; Actinobacillus actinomycetemcomitans; 細胞接着; E-cadherin; 細胞増殖

Periodontal disease, chronic inflammation disease, is caused by infection of periodontal pathogen. It is thought that about 80% of Japanese are affected and it is a major cause of tooth loss. It is still unknown that the difference of progression of periodontal disease for each patient. It is thought that the attachment between gingival epithelial cells and tooth is a physical barrier from infection, and this attachment is important for prevention of periodontal disease. In this study, we hypothesis that growth factors secretes from gingival epithelial cells regulate the attachment between gingival epithelial cells and tooth, and we investigate the mechanism about the regulation.

牙周病是由牙周致病菌感染引起的慢性炎症性疾病。据认为，大约80%的日本人受到影响，这是牙齿脱落的主要原因。目前尚不清楚每个患者牙周病进展的差异。牙龈上皮细胞与牙齿之间的附着被认为是防止感染的物理屏障，这种附着对于牙周病的预防是重要的。本研究假设牙龈上皮细胞分泌的生长因子调节牙龈上皮细胞与牙齿的粘附，并探讨其调节机制。

项目成果

歯肉上皮細胞において外因性Smad2は細胞接着分子の発現を促進する

外源性Smad2促进牙龈上皮细胞细胞粘附分子的表达

• 发表时间: 2011
• 作者: 本郷昌一;山城圭介
• 通讯作者: 山城圭介

Aggregatibacter actinomycetemcomitansがヒト歯肉上皮細胞の細胞接着因子に及ぼす影響

放线菌聚集杆菌对人牙龈上皮细胞粘附因子的影响

• 发表时间: 2011
• 作者: 高知信介;山城圭介
• 通讯作者: 山城圭介