The functional role of angiotensin receptor-binding molecule in chronic kidney disease and metabolic disorders.

点击翻译按钮获取中文摘要

The AT1 receptor(AT1R)-associated protein(ATRAP) is a molecule specifically interacting with the carboxyl-terminal domain of AT1R. In the present study, we demonstrated that a kidney-specific regulatory balancing of ATRAP and AT1R expression may be involved in the modulation of AT1R signaling at local tissue sites and also in the pathophysiology of hypertension and its associated renal injury. Furthermore, we showed that AT1R blockade, ARB, attenuated hypertension and renal injury concomitant with the sustained recovery of renal ATRAP expression. These results suggest that ATRAP can be a novel therapeutic target in chronic kidney disease.