The functional role of angiotensin receptor-binding molecule in chronic kidney disease and metabolic disorders.

血管紧张素受体结合分子在慢性肾脏疾病和代谢紊乱中的功能作用。

• 批准号: 22890150
• 负责人: WAKUI Hiromichi
• 金额: $ 1.96万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890150/
• 关键词: レニンアンジオテンシン系; 受容体; 慢性腎臓病; 高血圧; メタボリック症候群; レニン-アンジオテンシン系

The AT1 receptor(AT1R)-associated protein(ATRAP) is a molecule specifically interacting with the carboxyl-terminal domain of AT1R. In the present study, we demonstrated that a kidney-specific regulatory balancing of ATRAP and AT1R expression may be involved in the modulation of AT1R signaling at local tissue sites and also in the pathophysiology of hypertension and its associated renal injury. Furthermore, we showed that AT1R blockade, ARB, attenuated hypertension and renal injury concomitant with the sustained recovery of renal ATRAP expression. These results suggest that ATRAP can be a novel therapeutic target in chronic kidney disease.

AT1受体(AT1R)相关蛋白(ATRAP)是一种与AT1R的羧基末端结构域特异结合的分子。在本研究中，我们证明了ATRAP和AT1R表达的肾脏特异性调节平衡可能参与了局部组织部位AT1R信号的调节，也参与了高血压及其相关肾脏损伤的病理生理学。此外，我们发现AT1R阻断、ARB、减轻高血压和肾脏损伤伴随着肾脏ATRAP表达的持续恢复。这些结果表明，ATRAP可以成为慢性肾脏疾病的一个新的治疗靶点。

项目成果

Cardiac-Specific Activation of Angiotensin II Type 1 Receptor–Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II–Infused Mice

• DOI: 10.1161/hypertensionaha.109.147207
• 发表时间: 2010-05
• 期刊: Hypertension
• 影响因子: 8.3
• 作者: H. Wakui;K. Tamura;Yutaka Tanaka;M. Matsuda;Y. Bai;Toru Dejima;Shin-ichiro Masuda;Atsu-ichiro Shigenaga;Akinobu Maeda;M. Mogi;Naoaki Ichihara;Yusuke Kobayashi;N. Hirawa;T. Ishigami;Y. Toya;M. Yabana;M. Horiuchi;S. Minamisawa;S. Umemura

Prepubertal angiotensin blockade exerts long-term therapeutic effect through sustained ATRAP activation in salt-sensitive hypertensive rats

• DOI: 10.1097/hjh.0b013e32834a5a46
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Dejima, Toru;Tamura, Kouichi;Umemura, Satoshi
• 通讯作者: Umemura, Satoshi

本研究成果により第9回腎と高血圧Update優秀賞受賞(平成23年12月)

该研究成果荣获第九届肾脏与高血压更新优秀奖（2011年12月）

Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice

血管紧张素 II 输注小鼠中血管紧张素 II 1 型受体结合分子的肾内抑制

• 发表时间: 2010
• 期刊: Am J Physiol Renal Physiol
• 作者: Wakui H;Tamura K;Matsuda M;Bai Y;Dejima T;Shigenaga A;Masuda S;Azuma K;Maeda A;Hirose T;Ishigami T;Toya Y;Yabana M;Minamisawa S;Umemura S.
• 通讯作者: Umemura S.

Involvement of Runx3 in the basal transcriptional activation of the mouse angiotensin II type 1 receptor-associated protein gene

• DOI: 10.1152/physiolgenomics.00005.2011
• 发表时间: 2011-07-01
• 期刊: PHYSIOLOGICAL GENOMICS
• 影响因子: 4.6
• 作者: Matsuda, Miyuki;Tamura, Kouichi;Umemura, Satoshi
• 通讯作者: Umemura, Satoshi