Development of the high blood pressure medical treatment by angiotensin receptor binding molecule

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We paid our attention to the functional role of renal tubule ATRAP in vivo, and, using renal tubule ATRAP overexpression transgenic mice, we examined functional role of renal tubule ATRAP in blood pressure regulation in response to pathologic stimulation. As a result, while ATRAP, with a high endogenous expression in renal tubules, preserves baseline physiological AT1R signaling activity, it would suppress pathological overactivation of AT1R signaling under pathological conditions. Furthermore, using vascular ATRAP overexpression transgenic mouse, we demonstrated that vascular ATRAP can suppress oxidative stress at local tissue sites and inhibit arteriosclerosis under pathological conditions.