The Regenerative Medicine in Mandibular Condylar Chondrocytes by The Application of Control Technology of Low-intensity Pulsed Ultrasound on the Matrix Metabolism

低强度脉冲超声基质代谢控制技术应用下颌髁突软骨细胞再生医学

• 批准号: 22890122
• 负责人: IWABUCHI Yasunori
• 金额: $ 1.54万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890122/
• 关键词: 歯学; 細胞・組織; シグナル伝達; 移植・再生医療; 再生医学

Stimulation over the opening cartilage for temporomandibular joint in rats, promote the secretion of IL-1βin the mesenchymal layer of cartilage, reduced the proteoglycan of hyaline cartilage layer of the surface cartilage and hyaluronic acid. By irradiation of a rat model of LIPUS for the opening over, a decrease in IL-1βcompared to the non-irradiated group, the increase in proteoglycan On the other hand was observed. Suppressor pathway for IL-1βof LIPUS, LIPUS pathways inhibited the enhancement of COX-2 and ERK-1/ 2 by activating integrin under inflammation, called to suppress the IL-1βhas been suggested.

刺激大鼠颞下颌关节开口软骨，促进软骨间充质层il -1β的分泌，降低软骨表面透明软骨层蛋白多糖和透明质酸。通过对大鼠LIPUS模型进行开孔照射，与未照射组相比，il -1β减少，另一方面观察到蛋白多糖增加。LIPUS的il -1β抑制通路，LIPUS通路在炎症下通过激活整合素抑制COX-2和ERK-1/ 2的增强，被认为是抑制il -1β。

项目成果

退行性変性を呈する下顎頭軟骨に対する低出力超音波(LIPUS)照射の影響について

低功率超声（LIPUS）照射对下颌髁突软骨退行性变的影响

• 发表时间: 2010
• 作者: Gaowa;Wuritu;Wu D.;Yoshikawa Y.;Ohashi N.;Kawamori F.;Sugiyama K.;Ohtake M.;Ohashi M.;Yamamoto S.;Kitano T.;Takada N. and Kawabata H;岩渕泰憲
• 通讯作者: 岩渕泰憲