Analysis of epigenetic changes which cause diabetes mellitus.-Interaction between epigenetic changes and nutritional adaptation systems-

糖尿病、营养状况和表观遗传修饰之间的相互作用是神秘的。首先，我们评估了营养适应因素。接下来，我们研究了哪些营养适应因子或糖尿病状况会影响胰腺β细胞的表观遗传修饰。受营养状况调节的代谢物调节表观遗传修饰。这种代谢物是由一种在糖尿病动物中表达失调的酶合成的。这些结果表明，营养或糖尿病状况影响代谢变化和表观遗传修饰。

Interactions among diabetes, nutritional status and epigenetic modification are mysterious. First we assessed nutritional adaptation factors. We next investigated which nutritional adaptation factors or diabetic conditions affect epigenetic modification in pancreatic beta-cells. A metabolite which is regulated by nutritional status regulates epigenetic modification. This metabolite is synthesis by an enzyme which expression was dysregulated in diabetic animals. These results suggest that nutritional or diabetic conditions affect metabolic changes and epigenetic modifications.