Relationship between diabetes and epigenetic modification regulated by ketone body metabolism
Relationship between diabetes and epigenetic modification regulated by ketone body metabolism
批准号:
24790244
负责人:
UEBANSO Takashi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
我研究了酮体代谢调控下的表观基因组修饰与脱髓鞘的关系。 两种代谢酮体的酶之一的敲低影响组蛋白H3的甲基化。 此外,酮体代谢的破坏影响胰腺β细胞中应激诱导的细胞毒性。 这些结果表明,酮体代谢连接表观基因组修饰和细胞功能。
英文摘要
I studied relationship between deiabetes and epigenome modification regulated by ketone body metabolism. Knock down of one of two enzyme which metabolise ketone body affect methylation of histone H3. Moreover, disruption of ketone body metabolism affect stress induced cytotoxicity in pancreatic beta cells. These results suggest that ketone body metabolism link epigenenome modification and cellular function.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
膵β細胞における、ケトン体代謝酵素BDH2の新規機能の解析
胰腺β细胞酮体代谢酶BDH2新功能分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[上番増喬, 他]
通讯作者:
他
The impact of ketone body metabolic flow on epigenomic modifications, cellular function, and the development of metabolic diseases.
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批准号:20K11624
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2020
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依托单位:
Creation of hybrid nutrition by integrating metabolic information from inside and outside the body
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批准号:18K19746
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Strategy for regulating the gut microbiota for nutritional approach of next generation
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依托单位:
Effect of interaction between metabolic flux and epigenetic modification on metabolic disease
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批准号:15H05647
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依托单位:
Analysis of epigenetic changes which cause diabetes mellitus.-Interaction between epigenetic changes and nutritional adaptation systems-
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依托单位:
海外基金