Mesenteric lymph node stromal cells influence the induction of chronic intestinal inflammation

肠系膜淋巴结基质细胞影响慢性肠道炎症的诱导

• 批准号: 453300282
• 负责人: Dr. Manuela Büttner
• 金额: --
• 依托单位: Zentrales Tierlabor und Institut für Versuchstierkunde
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/453300282?language=en
• 关键词: Mesenteric; lymph; node; stromal; cells

The balance between the responsiveness of the intestinal immune system and the gut environment is fundamental for the maintenance of the intestinal homeostasis, which is required for an adequate recognition of entering antigens. The disruption of this homeostasis by exaggerated immune response to harmless antigens can lead to the development of intestinal disorders such as inflammatory bowel disease. Mesenteric lymph nodes (mLNs) are an important site for the immune response induction, but also contribute to the immune response and tolerance induction in the intestine. The mLNs consist of several specific intestine draining lymph nodes and their backbone is built by sessile non-hematopoietic stromal cells. However, the knowledge about the role of the colon draining mLN as well as stromal cells in the regulation of inflammatory responses is still limited. Therefore, we aim to analyze the influence of the colon-draining mLN as well as stromal cells of the mLN on the development of intestinal inflammation. We will use a chronic intestinal inflammation model such as the IL10-deficient mouse but also a C. rodentium infection model.

肠道免疫系统的反应性和肠道环境之间的平衡是维持肠道稳态的基础，这是充分识别进入抗原所必需的。对无害抗原的过度免疫反应破坏了这种稳态，可能导致炎症性肠病等肠道疾病的发生。肠系膜淋巴结（mLN）是诱导免疫反应的重要部位，也有助于肠道内的免疫反应和耐受诱导。 mLN 由几个特定的​​肠道引流淋巴结组成，其骨干由无柄非造血基质细胞构成。然而，关于结肠引流 mLN 以及基质细胞在炎症反应调节中的作用的知识仍然有限。因此，我们的目的是分析结肠引流 mLN 以及 mLN 基质细胞对肠道炎症发展的影响。我们将使用慢性肠道炎症模型，例如 IL10 缺陷小鼠，以及啮齿类梭菌感染模型。