Drug delivery to redox-disease site using an artificial virus

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Traditional drug carriers do not have sufficient selectivity to disease cells. In this research, a naturally occurring protein cage, Hsp16.5, was fabricated to selectively deliver cargos into hepatoma cells through chemical and genetic methods. Resulting fabricated Hsp16.5 cages were selectively taken up by hepatoma cells, but not by normal hepatocyte. When conjugate with doxorubicin (DOX) and hepatoma-targetable Hsp were added to hepatoma and normal hepatocyte, cytotoxicity of this conjugates to hepatoma was comparable with that of free DOX, whereas this conjugates drastically reduced cytotoxicity to normal hepatocyte.