Effects of remote ischemic preconditioning on cardiac sympathetic nerve and elucidation of cardioprotection mechanism

远程缺血预处理对心脏交感神经的影响及心脏保护机制的阐明

• 批准号: 23800078
• 负责人: UEDA Shinya
• 金额: $ 2.08万
• 依托单位: Morinomiya University of Medical Sciences (2012)National Cardiovascular Center Research Institute (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23800078/
• 关键词: 遠隔虚血プレコンディショニング(RIPC); 心臓自律神経; 心臓マイクロダイア リシス法; エピネフリン; ノルエピネフリン; 遠隔虚血プレコンディショニング; 心臓マイクロダイアリシス法; ノルエピネフリン（NE）; エピネフリン（Epi）; Remote Ischemic Preconditioning

In the present study, we examined the effects of remote ischemic preconditioning (RIPC) on myocardial interstitial norepinephrine (NE) and epinephrine (Epi) levels in the rabbit left ventricle in vivo using microdialysis. As a result, the increase in dialysate NE levels until 30 min of coronary occlusion were significantly enhanced by RIPC. In addition, the suppression of dialysate NE levels during coronary artery occlusion by RIPC do not act so much cardiac sympathetic nerve function changing as other mechanism. Further study is required to elucidate the interplay between neural and humoral pathways underlyingcardioprotection by RIPC.

在本研究中，我们研究了远程缺血预处理（RIPC）对心肌间质去甲肾上腺素（NE）和肾上腺素（Epi）在兔左心室在体微透析水平的影响。结果，RIPC显著增强了透析液NE水平的增加，直至冠状动脉闭塞30分钟。此外，RIPC抑制冠脉阻塞期间透析液NE水平的作用并不像其他机制那样引起心脏交感神经功能的改变。需要进一步研究阐明RIPC心肌保护作用中神经和体液途径之间的相互作用。

项目成果

3ヵ月間の運動トレーニングが運動刺激に対する摂食調節ホルモンの応答および食事摂取量に与える影響

3个月运动训练对摄食调节激素对运动刺激和膳食摄入反应的影响

• 作者: 大澤拓也;山本正嘉;上田真也 他
• 通讯作者: 上田真也 他

Effect of polymorphisms in beta3-adrenergic receptor and uncoupling protein 1 genes on metabolism during exercise in athletes

β3-肾上腺素受体和解偶联蛋白1基因多态性对运动员运动代谢的影响

• 发表时间: 2013
• 期刊: Bulletin of Morinomiya University of Medical Sciences
• 作者: Ueda SY;Miyamoto T;Nakahara H;Shishido T;Usui T;Katsura Y;Yoshikawa T;Fujimoto S.;Ueda S et al.
• 通讯作者: Ueda S et al.

Differences in Physiological Characterization between Yo-Yo Intermittent Recovery Test Level 1 and Level 2 in Japanese College Soccer Players

日本大学生足球运动员悠悠球间歇恢复测试1级和2级生理特征的差异

• 发表时间: 2011
• 期刊: International Journal of Sport and Health Science
• 作者: Ueda S;Yamanaka A;Yoshikawa T;Katsura Y;Usui T;Orita K;Fujimoto S
• 通讯作者: Fujimoto S

Effects of Aquatic Exercise Training Using New Water-resistance Equipment on Trunk Muscles, Abdominal Circumference, and Activities of Daily Living in Elderly Women

新型防水器材水上运动训练对老年妇女躯干肌肉、腹围及日常生活活动的影响

• 发表时间: 2011
• 期刊: International Journal of Sport and Health Science
• 作者: Katsura T;Ueda S;Yoshikawa T;Usui T;Orita K;Sakamoto H;Sotobayashi D;Fujimoto S
• 通讯作者: Fujimoto S

Effects of exercise training on gut hormone levels after a single bout of exercise in middle-aged Japanese women.

• DOI: 10.1186/2193-1801-2-83
• 发表时间: 2013-12
• 期刊: SpringerPlus
• 作者: Ueda SY;Miyamoto T;Nakahara H;Shishido T;Usui T;Katsura Y;Yoshikawa T;Fujimoto S
• 通讯作者: Fujimoto S