Spray drying system for non-aqueous feeds

非水饲料喷雾干燥系统

• 批准号: 453463631
• 金额: --
• 依托单位: Technische Universität Dortmund
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/453463631?language=en
• 关键词: Spray; drying; system; non; aqueous

Due to a change in research interest towards pharmaceutical products, a new spray tower is required capable to handle organic liquids as well as using nitrogen as drying gas in a closed system. Submicron particles (0.1-1µm) should be produced designing new dispersing systems in order to increase the dissolution rate of active pharmaceutical ingredients. Furthermore, new formulation concepts like amorphous solid dispersions should be developed and tested where the low soluble drug is imbedded in hydrophilic polymer. These technologies should be used to overcome the low bioavailability of new drug molecules that is considered the main limitation in pharmaceutical development of these days.

由于对制药产品的研究兴趣发生了变化，因此需要一个新的喷塔来处理有机液体以及在封闭系统中使用氮作为干燥气体。应生产次子颗粒（0.1-1μm）设计新的分散系统，以提高活性药物成分的溶解速率。此外，应开发和测试新的配方概念，例如在亲水性聚合物中嵌入低固体药物的情况下。这些技术应用于克服新药物分子的生物利用度低，这被认为是当今药品开发的主要限制。