Spray drying system for non-aqueous feeds

非水饲料喷雾干燥系统

• 批准号: 453463631
• 金额: --
• 依托单位: Technische Universität Dortmund
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/453463631?language=en
• 关键词: Spray; drying; system; non; aqueous

Due to a change in research interest towards pharmaceutical products, a new spray tower is required capable to handle organic liquids as well as using nitrogen as drying gas in a closed system. Submicron particles (0.1-1µm) should be produced designing new dispersing systems in order to increase the dissolution rate of active pharmaceutical ingredients. Furthermore, new formulation concepts like amorphous solid dispersions should be developed and tested where the low soluble drug is imbedded in hydrophilic polymer. These technologies should be used to overcome the low bioavailability of new drug molecules that is considered the main limitation in pharmaceutical development of these days.

由于对医药产品的研究兴趣的变化，需要一种新的喷雾塔，能够处理有机液体以及在封闭系统中使用氮气作为干燥气体。应设计新的分散系统来生产亚微米颗粒（0.1-1µm），以提高活性药物成分的溶出速率。此外，应开发和测试新的制剂概念，如无定形固体分散体，其中低可溶性药物嵌入亲水性聚合物中。这些技术应该被用来克服新药分子的低生物利用度，这被认为是当今药物开发的主要限制。