Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome
Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome
批准号:
10594793
负责人:
Ian M White
金额:
$39.28万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-03-01 至 2025-01-31
关键词:
Accident and Emergency departmentAcuteAcute Respiratory Distress SyndromeAdmission activityAlkanesAnti-Inflammatory AgentsAntibodiesAutomationBenchmarkingBindingBiological AssayBloodBlood VesselsBlood capillariesBlood specimenBody partCell DeathCellsCirculationClinicalCytolysisDNADataDeath RateDetectionDiagnosticEarly DiagnosisEdemaEnvironmentEnzyme-Linked Immunosorbent AssayFingersFreeze DryingGoalsHemorrhageHeparinHistonesImmuneIncidenceInfectionInflammatory ResponseInjuryIntellectual PropertyInvestmentsLabelLifeLinkLungManualsMeasurementMeasuresMorbidity - disease rateOperating RoomsOpticsOrganOutcomePatient riskPatientsPerformancePhasePoint-of-Care SystemsPreventive treatmentReagentRefrigerationReportingResearchRespiration DisordersRiskRisk AssessmentSamplingSecureShockSyndromeSystemTechnologyTemperatureThrombosisTraumaTrauma patientTraumatic injuryTubeVacuumValidationVenousWhole Bloodcommercializationdesigndiagnostic technologiesdiagnostic toolimprovedinnovationinstrumentinventionlung failurelung injurymeetingsmortalityneutrophilpoint of carepoint of injuryportabilitypreservationpreventprototypesample collectiontrauma centers
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
Trauma-induced acute respiratory dysfunction syndrome (ARDS) is a deadly condition in which lung failure
results from a traumatic injury to another part of the body. Recently, several studies have established a link
between circulating histones and lung failure. Traumatic injuries cause a massive amount of cell death,
resulting in the release of high concentrations of histones into circulation, which can directly lead to ARDS, as
histones damage the lungs. In addition, circulating histones exacerbate exaggerated pro- and anti-
inflammatory responses that also result in damage to the lungs and other organs. Identification and
quantification of trauma-triggered circulating histones would provide an approach to assess the risk of ARDS,
which could enable life-saving therapies before a patient develops ARDS. Diagnostic solutions to provide early
detection of histones following trauma should be portable and rapid in order to assess the patient soon after
the injury occurs. Currently, however, there are no portable and rapid approaches that enable detection of
circulating histones to assess a trauma patient’s risk of developing ARDS. Our goal is to develop a diagnostic
tool that is capable of quantitatively assessing the risk of trauma-induced ARDS at the point of care. This may
include at the point of injury, in the transport vehicle to a trauma center, in the Emergency Department (ED), or
in the operating room (OR). We have invented a Portable Histone Assay Technology (PHAST) that can
quantify circulating histones directly from whole blood within 30 minutes.
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会议论文
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依托单位:
海外基金