Design and Synthesis of Novel Immunostimulatory Molecules Based on α-Galactosyl Ceramides

基于α-半乳糖基神经酰胺的新型免疫刺激分子的设计与合成

• 批准号: 23880011
• 负责人: IMAMURA Akihiro
• 金额: $ 2.08万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23880011/
• 关键词: 糖脂質; 免疫賦活; 有機合成; NKT細胞; ガラクトシルセラミド; グリコシル化; 抗腫瘍; 糖鎖; 免疫学; 複合糖質

Novel immunostimulators based on α-galactosyl ceramides were designed and synthesized by using a unique synthetic method developed by our group. Synthesis of α-galactoside/galactosaminide as a key structure was efficiently accomplished by DTBS-directed α-galactosylation developed by us. Fully protected framework of a target molecule was synthesized successfully. Unfortunately, however, poor soluble property of the target molecule produced after deprotection obliged us to redesign the structure of target molecules. We are currently trying to synthesize the redesigned molecule that is shortened the length of fatty acid in the ceramide moiety.

采用本课题组开发的独特合成方法，设计合成了基于α-半乳糖神经酰胺的新型免疫刺激剂。通过我们开发的DTBS引导的α-半乳糖基化，有效地完成了作为关键结构的α-半乳糖苷/半乳糖胺的合成。成功合成了目标分子的完全受保护的框架。然而不幸的是，脱保护后产生的目标分子的可溶性较差，迫使我们重新设计目标分子的结构。我们目前正在尝试合成重新设计的分子，该分子缩短了神经酰胺部分中脂肪酸的长度。