Design and Synthesis of Novel Immunostimulatory Molecules Based on α-Galactosyl Ceramides

利用本课题组开发的一种独特的合成方法，设计并合成了基于α-半乳糖基神经酰胺的新型免疫刺激剂。α-半乳糖苷/半乳糖胺作为关键结构的合成是由本实验室自行开发的α-半乳糖基化反应高效完成的。成功地合成了完全保护的目标分子骨架。然而，不幸的是，去保护后产生的目标分子的溶解性很差，迫使我们重新设计目标分子的结构。我们目前正在尝试合成重新设计的分子，它缩短了神经酰胺部分中的脂肪酸长度。

Novel immunostimulators based on α-galactosyl ceramides were designed and synthesized by using a unique synthetic method developed by our group. Synthesis of α-galactoside/galactosaminide as a key structure was efficiently accomplished by DTBS-directed α-galactosylation developed by us. Fully protected framework of a target molecule was synthesized successfully. Unfortunately, however, poor soluble property of the target molecule produced after deprotection obliged us to redesign the structure of target molecules. We are currently trying to synthesize the redesigned molecule that is shortened the length of fatty acid in the ceramide moiety.