Design and Synthesis of Novel Immunostimulatory Molecules Based on α-Galactosyl Ceramides

本课题组采用独特的合成方法，设计并合成了基于α-半乳糖神经酰胺的新型免疫刺激剂。通过我们开发的DTBS-α-半乳糖基化反应，有效地合成了关键结构α-半乳糖苷/半乳糖胺。成功地合成了一个完全保护的目标分子骨架。然而，不幸的是，脱保护后产生的靶分子的溶解性差迫使我们重新设计靶分子的结构。我们目前正在尝试合成重新设计的分子，即缩短神经酰胺部分中脂肪酸的长度。

Novel immunostimulators based on α-galactosyl ceramides were designed and synthesized by using a unique synthetic method developed by our group. Synthesis of α-galactoside/galactosaminide as a key structure was efficiently accomplished by DTBS-directed α-galactosylation developed by us. Fully protected framework of a target molecule was synthesized successfully. Unfortunately, however, poor soluble property of the target molecule produced after deprotection obliged us to redesign the structure of target molecules. We are currently trying to synthesize the redesigned molecule that is shortened the length of fatty acid in the ceramide moiety.