Study on the role of avian uncoupling protein in heat stress-induced overproduction of mitochondrial reactive oxygen species and the regulation mechanism of the expression in birds

肉鸡在热应激条件下，骨骼肌解偶联蛋白(AvUCP)的表达降低，这可能是通过增加线粒体膜电位而导致线粒体活性氧(ROS)的过量产生。本研究表明，热应激诱导的线粒体ROS在蛋鸡肌肉线粒体中的表达相对高于肉鸡，而在肉鸡中，其avUCP的表达随着日粮中橄榄油和橄榄油的摄入而上调。从这些结果可以想象，avUCP的表达可能在抑制热暴露引起的线粒体ROS的过度产生和氧化损伤方面发挥重要作用。

On exposure of meat-type chickens to heat stress, avian uncoupling protein (avUCP) expression in the skeletal muscle was decreased, which was involved in the overproduction of mitochondrial reactive oxygen species production (ROS) probably via an increase in the mitochondrial membrane potential. This study demonstrates that the heat stress-induced overproduction of mitochondrial ROS did not occur in the muscle mitochondria of laying-type chickens, whose avUCP expression is relatively higher than that of meat-type ones, and in mitochondria of meat-type chickens whose avUCP expression was up-regulated with dietary intake of olive oil and oleuropein. From these results, it is conceivable that avUCP expression may play an important role in suppressing the overproduction of mitochondrial ROS and oxidative damage caused by heat exposure.