Elucidation of a novel DNA repair system from extremophiles and application to exploit of an available host.

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A novel proteins likely involved in multiple DNA repair systems were found in extremophiles. These proteins are comprised of two domains, an alkylated lesion repair protein-like domain in N-terminus and an Endonuclease V (EndoV)-like domain, deamination repair protein, in C-terminus. However, the pathways which is involved in these novel proteins are completely unknown. Since the most of extremophiles are unculturable and their genome sequences are unclear, the novel DNA repair systems potentially act in important pathway from extremophiles. From my prediction, it is important as applications and basic science to elucidate the functions of these novel proteins, AGT-EndoV and ATL-EndoV. I tried to elucidate the function in this project.