Analysis of Plasmacytoid Dendritic Cells in Nasal Epithelium ofallergic rhinitis

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Chronic rhinosinusitis with nasal polyps (CRSwNPs) is generally Chronic rhinosinusitis with nasal polyps (CRSwNPs) is generally characterized by local Th2 inflammation. In Japan, CRSwNPs is categorized into two subtypes: eosinophilic chonic rhinosinusitis (ECRS) that is similar to the CRSwNPs in western countries, and non-eosinophilic chronic rhinosinusits (non-ECRS) which is characterized by Th1-dominant inflammation. I compared immune cell profiles with ECRS and non-ECRS. The number of innate immune cell2(ILC2) increased at ECRS, it suggests that human ILC2 provides an innate source of Th2 cytokines.