Expression of PRL-3 and its clinicopathologic significance in oral squamous cell carcinoma

再生肝蛋白磷酸酶-3(PRL-3)在口腔鳞癌和异型增生组织中的表达明显高于正常口腔黏膜组织。PRL-3的表达与组织分化程度和侵袭方式的组织学分级有关。4-硝基喹啉1-氧化物致癌大鼠舌鳞状细胞癌和异型增生组织中PRL-3表达增加。我们的结果提示PRL-3在肿瘤发生中起关键作用，它可能是口腔癌进展的一个新的标记物。

Protein phosphatase of regenerating liver-3 (PRL-3) expressions were significantly higher in oral squamous cell carcinoma and oral epithelial dysplasia than in normal mucosa. PRL-3 expression were correlated with histological differentiation and histological grading of mode of invasion. PRL-3 expression was increased in squamous cell carcinoma and epithelial dysplasia in rat tongue carcinogenesis by 4-nitroquinoline 1-oxide. Our results suggest that PRL-3 plays a key role in tumorigenesis and it may be a novel marker of oral cancer progression.