Expression of PRL-3 and its clinicopathologic significance in oral squamous cell carcinoma

PRL-3在口腔鳞癌中的表达及其临床病理意义

• 批准号: 23890125
• 负责人: YOSHIDA Shoko
• 金额: $ 2.08万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890125/
• 关键词: PRL-3; 口腔扁平上皮癌

Protein phosphatase of regenerating liver-3 (PRL-3) expressions were significantly higher in oral squamous cell carcinoma and oral epithelial dysplasia than in normal mucosa. PRL-3 expression were correlated with histological differentiation and histological grading of mode of invasion. PRL-3 expression was increased in squamous cell carcinoma and epithelial dysplasia in rat tongue carcinogenesis by 4-nitroquinoline 1-oxide. Our results suggest that PRL-3 plays a key role in tumorigenesis and it may be a novel marker of oral cancer progression.

再生肝蛋白磷酸酶-3 （PRL-3）在口腔鳞状细胞癌和口腔上皮异常增生组织中的表达明显高于正常黏膜组织。PRL-3表达与组织分化及侵袭方式的组织学分级相关。PRL-3在4-硝基喹啉- 1-氧化物致大鼠舌癌的鳞状细胞癌和上皮异常增生中表达升高。我们的研究结果表明，PRL-3在肿瘤发生中起着关键作用，它可能是口腔癌进展的新标志物。

项目成果

Increased Expression of the PRL-3 Gene in Human Oral Squamous Cell Carcinoma and Dysplasia Tissues

PRL-3 基因在人口腔鳞状细胞癌和不典型增生组织中表达增加

• 发表时间: 2011
• 期刊: Asian Pac J Cancer Prev.
• 作者: Beatrice Lecroq;Franck Lejzerowicz;Jan Pawlowski;Philippe Esling;Loic Baerlocher;Laurent Farinelli;Magne Osteras;Katase N;Fujii M;Hassan NM
• 通讯作者: Hassan NM

口腔扁平上皮癌におけるサイトケラチンの発現についての検討

口腔鳞癌中细胞角蛋白表达的研究

• 发表时间: 2012
• 作者: Sugimoto Y;Tanaka M;Misawa H;Takigawa T;Tetsunaga T;Shiozaki Y;吉田祥子
• 通讯作者: 吉田祥子

Increased expression of the PRL-3 gene in human oral squamous cell carinoma and dysplasia tissues

PRL-3基因在人口腔鳞状细胞癌和不典型增生组织中表达增加

• 发表时间: 2011
• 期刊: Asian Pac J Cancer Prev
• 作者: Fukushima H.;Kawanabe N.;Murata S.;Ishihara Y.;Yanagita T.;Balam TA.;Yamashiro T;Hassan NM
• 通讯作者: Hassan NM

Expression of cytokeratin in development, invasion and metastasis of oral squamous cell carcinoma

细胞角蛋白在口腔鳞癌发生发展、侵袭和转移中的表达

• 发表时间: 2012
• 作者: Yo sh id a S;Kishimoto K;HASSAN NMM;Domae S,Yoshioka N;Sasaki A
• 通讯作者: Sasaki A