DNA methylation analysis of the BCL6 translocation partners in malignant lymphoma

恶性淋巴瘤中 BCL6 易位伴侣的 DNA 甲基化分析

• 批准号: 21659086
• 负责人: YOSHIDA Shoko
• 金额: $ 1.29万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659086/
• 关键词: 悪性リンパ腫; DNAメチル化; BCL6転座

This study was carried out to examine the DNA methylation status of the BCL6 translocation partner gene, particularly the CpG island within the frequently mutated regions, among the cases with malignant lymphoma to study whether it affects the expression or mutagenesis of the partner gene, and whether it is associated with the subtypes or prognosis of the malignant lymphoma. The present study indicated that the DNA methylation status of CpG islands of the partner genes did not affect the expression or mutagenesis of the genes.

本研究检测BCL6易位伙伴基因DNA甲基化状态，特别是频繁突变区域的CpG岛，以研究其是否影响伙伴基因的表达或突变，以及它是否与恶性淋巴瘤的亚型或预后有关。本研究表明，配对基因CpG岛的DNA甲基化状态不影响基因的表达或突变。