The Research of Sex Hormonal Influence on the Meibomian Gland and the Ocular Surface Epithelium

性激素对睑板腺和眼表上皮影响的研究

• 批准号: 23890181
• 负责人: SUZUKI Tomo
• 金额: $ 1.91万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890181/
• 关键词: ドライアイ; マイボーム腺; 性ホルモン; マイボーム腺機能不全; 脂肪酸分析; 加齢; 酒さ

In the present study, the methods of collection for meibomian gland secretion (meibum) without contamination were reevaluated and the analysis of fatty acid (FA) composition of meibum was conducted. In healthy volunteers meibum was composed of 40% saturated and 60% unsaturated FAs. In unsaturated Fas branched FAs were dominant and in unsaturated FAs monounsaturated was the major component. In premenstrual women the FA composition changed according to their menstrual cycle.

在本研究中，重新评估了无污染的睑板腺分泌物（meibum）的收集方法，并进行了睑板腺分泌物脂肪酸（FA）组成的分析。健康志愿者的新陈代谢由40%的饱和脂肪酸和60%的不饱和脂肪酸组成。在不饱和脂肪酸中，支链脂肪酸占主导地位，单不饱和脂肪酸占主要成分。经前期妇女FA成分随月经周期变化。

项目成果

Clinical Similarities among Meibomitis-Related Keratoconjunctivitis

睑板腺炎相关角结膜炎的临床相似性

• 发表时间: 2012
• 作者: Suzuki T;Sano Y;Yokoi N;Kinoshita S
• 通讯作者: Kinoshita S

感染アレルギー疾患の診断と治療

传染性过敏性疾病的诊断和治疗

• 发表时间: 2012
• 作者: Nakatsukasa M;Sotozono C;Shimbo K;Ono N;Miyano H;Okano A;Hamuro J;Kinoshita S;角野雅春;鈴木 智
• 通讯作者: 鈴木 智

あたらしい眼科

新眼科

• 发表时间: 2021
• 作者: 富田洋平;栗原俊英
• 通讯作者: 栗原俊英

Influence of Aromatase Absence on the Gene Expression and Histology of the Mouse Meibomian Gland

• DOI: 10.1167/iovs.12-10992
• 发表时间: 2013-02-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Darabad, Raheleh Rahimi;Suzuki, Tomo;Sullivan, David A.
• 通讯作者: Sullivan, David A.

The Composition of Fatty Acids in Human Meibum

人睑脂中脂肪酸的组成

• 发表时间: 2013
• 作者: Suzuki T;Kamada S;Tajika T;Fujiwara S;Kinoshita S
• 通讯作者: Kinoshita S