New function of LPA3 receptor that regulates vagal afferent nerves activation

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In this study, we assessed the functional effects of LPA3 signal-induced vagal excitation and quantifying LPA and other lysophospholipids level in myocardial infarction.We found that injection of LPA3 agonist named T13, which is 2-acyl LPA analog, significantly decreased infact area in acute ischemic injury model. We analyzed clinical specimen (plasma) from acute coronary syndrome (ACS) patients by LC-MS/MS, and found unsaturated LPA, which show potent agonist activity for LPA3, were selectively elevated in ACS. In addition, other unsaturated lysophospholipids (LPC, LPE, LPG, LPI, LysoPS) were also increased. These results suggest that unsaturated LPA are produced by increased substrates of autotaxin in myocardial infarction.