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Imaging of microglial activation in anorexia nervosa by new PET tracer.

Imaging of microglial activation in anorexia nervosa by new PET tracer.
通过新型 PET 示踪剂对神经性厌食症中的小胶质细胞激活进行成像。
批准号:
24890083
负责人:
YOKOKURA Masamichi
金额:
$1.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31

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中文摘要
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英文摘要
A number of findings from clinical and animal studies indicate that the immune system is altered in anorexia nervosa (AN). We measured the levels of activated microglia in AN by a new tracer [11C]DPA713 positron emission tomography (PET).First, [11C]DPA713 PET in 13 healthy subjects established that a non-invasive analytic method, which is simplified reference tissue model (SRTM), is applicable to human subjects in [11C]DPA713 PET, and showed that the [11C]DPA713 has a higher signal-to-noise ratio than [11C]PK11195, which is the most common PET tracer for activated microglia. Second, [11C]DPA713 PET in 9 AN subjects showed the increased levels of activated microglia in global region of brain.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
In vivo imaging of neuroinflammation using a new PET tracer [^11C]DPA713
使用新型 PET 示踪剂 [^11C]DPA713 对神经炎症进行体内成像
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [M Yokokura, Y Ouchi, K Takebayashi, Y Iwata, N Mori]
通讯作者: N Mori
Imaging of microglial activation in the living human brain using a new PET tracer [11C]DPA713
使用新型 PET 示踪剂 [11C]DPA713 对活人大脑中的小胶质细胞激活进行成像
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Masamichi Yokokura, Yasuomi Ouchi, Kiyokazu Takebayashi, Yasuhide Iwata, Tatsuhiro Terada, Kyoko Nakaizumi, Norio Mori]
通讯作者: Norio Mori
Depiction of microglial activation in the living human brain by different TSPO tracers
不同 TSPO 示踪剂对活人大脑中小胶质细胞激活的描述
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Yokokura, Y Ouchi, K Takebayashi, Y Iwata, T Terada, K Nakaizumi, N Mori]
通讯作者: N Mori
Imaging of microglial activation in the living human brain using a new PET tracer [^11C]DPA713
使用新的 PET 示踪剂 [^11C]DPA713 对活人大脑中的小胶质细胞激活进行成像
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [M Yokokura, Y Ouchi, K Takebayashi, Y Iwata, T Terada, K Nakaizumi, N Mori]
通讯作者: N Mori
The PET study of drug-naive schizophrenia using double tracers : involvements of dopaminergic system and microglia.
  • 批准号:
    21791128
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2009
  • 负责人:
    YOKOKURA Masamichi
  • 依托单位:
海外基金