Analyses of predictive factors from hepatitis to cirrhosis using metabolomics

使用代谢组学分析从肝炎到肝硬化的预测因素

• 批准号: 24890126
• 负责人: MASAYA Saito
• 金额: $ 1.91万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890126/
• 关键词: 肝硬変; 肝線維化; 肝炎

Using liver biopsy, hepatitis was induced in mice with coline-deficient diet for 4 weeks, but not in mice without coline-deficient diet. Serum level of taurine decreased in mice with coline-deficient diet for 4 weeks. In mice with coline-deficient diet for 8 weeks, liver tissue showed cirrhosis from hepatitis.In cirrhotic mice, moreover, serum level of taurine decreased compared with that of hepatitis mice. Therefore, serum taurine would negatively be associated with liver fibrosis in mice. In human as well as mice, serum level of taurine was negatively associated with liver fibrosis. We thought that serum level of taurine would be a predictive marker of liver fibrosis.

使用肝活检，用缺乏科林的饮食4周的小鼠中诱导肝炎，但在没有缺乏科林的饮食的小鼠中没有。低胆固醇饮食4周后，小鼠血清牛磺酸水平下降。8周后，低胆固醇饮食小鼠肝组织出现肝炎肝硬化，且血清牛磺酸水平较肝炎组降低。因此，血清牛磺酸与小鼠肝纤维化呈负相关。在人类和小鼠中，血清牛磺酸水平与肝纤维化呈负相关。我们认为血清牛磺酸水平可能是肝纤维化的一个预测指标。

项目成果

Portal venous tumor growth-type of hepatocellular carcinoma without liver parenchyma tumor nodules: a case report

• DOI: 10.1016/s1665-2681(19)31304-3
• 发表时间: 2013-11-01
• 期刊: ANNALS OF HEPATOLOGY
• 影响因子: 3.8
• 作者: Saito, Masaya;Seo, Yasushi;Azuma, Takeshi
• 通讯作者: Azuma, Takeshi

Alteration of non-protein respiratory quotient after hepatocellular carcinoma treatment can be related to des-γ-carboxy prothrombin before treatment.

• DOI: 10.1186/2193-1801-1-55
• 发表时间: 2012
• 期刊: SpringerPlus
• 作者: Saito M;Seo Y;Yano Y;Miki A;Momose K;Hirano H;Yoshida M;Azuma T
• 通讯作者: Azuma T

A Hepatocellular Carcinoma Developed Following 18 Years from Sustained Virological Response to Interferon Therapy in a Patient with Chronic Hepatitis C : Case Report and Literature Review

慢性丙型肝炎患者对干扰素治疗持续病毒学反应 18 年后发展为肝细胞癌：病例报告和文献综述

• 发表时间: 2012
• 期刊: Clin J Gastroenterol
• 影响因子: 1
• 作者: Masaya Saito;Yasushi Seo;Yoshihiko Yano;Akira Miki;Yukiko Morinaga;Tomoo Itoh;Masaru Yoshida;Takeshi Azuma
• 通讯作者: Takeshi Azuma

Sonazoid-enhanced ultrasonography and Ga-EOB-DTPA-enhanced MRI of hepatic inflammatory pseudotumor : a case report

肝炎性假瘤的 Sonazoid 增强超声检查和 Ga-EOB-DTPA 增强 MRI：一例报告

• 发表时间: 2012
• 期刊: Intern Med
• 作者: Masaya Saito;Yasushi Seo;Yoshihiko Yano;Akira Miki;Yukiko Morinaga;Tomoo Itoh;Masaru Yoshida;Takeshi Azuma
• 通讯作者: Takeshi Azuma

Branched-chain amino acid granules improve non-protein respiratory quotient after radiofrequency ablation.

支链氨基酸颗粒改善射频消融后非蛋白质呼吸商。

• 发表时间: 2014
• 期刊: Intern Med
• 作者: Masaya Saito;Yoshihiko Yano;Akihiro Minami;Hirotaka Hirano;Kenji Momose;Maki Sugimoto;Masaru Yoshida;Takeshi Azuma.
• 通讯作者: Takeshi Azuma.