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Development of novel therapeutic agents for temporomandibular joint disease and elucidation of expression control mechanism of lubricating function protein SZP

Development of novel therapeutic agents for temporomandibular joint disease and elucidation of expression control mechanism of lubricating function protein SZP
颞下颌关节病新型治疗药物的开发及润滑功能蛋白SZP表达控制机制的阐明
批准号:
24890140
负责人:
MITSUYOSHI Tomomi
金额:
$1.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31

项目摘要

项目成果

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中文摘要
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英文摘要
It was showned that HA formulations were effective for SZP expression and joint lubrication and providing a protective barrier for the cells in the deep zone of cartilage in early OA. Moreover, it was suggested that HA affects SZP expression. Interaction between SZP and HA in articular cartilage may be critical for proper lubricating function on the surface of articular cartilage.
期刊论文(8)
专著(0)
科研奖励(0)
会议论文
ヒアルロン酸およびSuperficial zone proteinが関節潤滑に及ぼす影響
透明质酸和浅表区蛋白对关节润滑的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Shintaro Nagayasu, Shigeki Suzuki, Akiko Yamashita, Ataru Taniguchi, Mitsuo Fukushima, Yoshikatsu Nakai, Naoya Watanabe, Shoichiro Nagasaka, Daisuke Yabe, Kazuko Nin, Fusanori Nishimura, 光吉智美]
通讯作者: 光吉智美
DOI: 10.1016/j.joca.2014.03.011
发表时间: 2014-06-01
期刊: OSTEOARTHRITIS AND CARTILAGE
影响因子: 7
作者: [Su, S. -C., Tanimoto, K., Tanne, K.]
通讯作者: Tanne, K.
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Y Taguchi, S Yamasaki, H Mukasa, A Shimamoto, H Tahara, T Okamoto, Tanne K]
通讯作者: Tanne K
Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow
流体流动调节滑膜细胞中透明质酸和浅表区蛋白的合成
DOI: --
发表时间: 2013
期刊: Eur J Oral Sci
影响因子: 1.9
作者: [Tamami Yanagida-Suekawa, Kotaro Tanimoto, Yuki Tanne, Tomomi Mitsuyoshi, Naoto Hirose, Shaoching Su, Kazuo Tanne and Eiji Tanaka]
通讯作者: Kazuo Tanne and Eiji Tanaka
海外基金