Development of novel therapeutic agents for temporomandibular joint disease and elucidation of expression control mechanism of lubricating function protein SZP

颞下颌关节病新型治疗药物的开发及润滑功能蛋白SZP表达控制机制的阐明

• 批准号: 24890140
• 负责人: MITSUYOSHI Tomomi
• 金额: $ 1.58万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890140/
• 关键词: 潤滑; ヒアルロン酸; 顎関節症; ＳＺＰ; SZP

It was showned that HA formulations were effective for SZP expression and joint lubrication and providing a protective barrier for the cells in the deep zone of cartilage in early OA. Moreover, it was suggested that HA affects SZP expression. Interaction between SZP and HA in articular cartilage may be critical for proper lubricating function on the surface of articular cartilage.

结果表明，透明质酸对早期OA的SZP表达和关节润滑有效，并为软骨深部区细胞提供保护屏障。此外，还提示HA影响SZP的表达。关节软骨中SZP和HA的相互作用可能是关节软骨表面正常润滑的关键。

项目成果

ヒアルロン酸およびSuperficial zone proteinが関節潤滑に及ぼす影響

透明质酸和浅表区蛋白对关节润滑的影响

• 发表时间: 2012
• 作者: Shintaro Nagayasu;Shigeki Suzuki;Akiko Yamashita;Ataru Taniguchi;Mitsuo Fukushima;Yoshikatsu Nakai;Naoya Watanabe;Shoichiro Nagasaka;Daisuke Yabe;Kazuko Nin;Fusanori Nishimura;光吉智美
• 通讯作者: 光吉智美

Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress

• DOI: 10.1016/j.joca.2014.03.011
• 发表时间: 2014-06-01
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Su, S. -C.;Tanimoto, K.;Tanne, K.
• 通讯作者: Tanne, K.

Current status of TMD.8th Asian Pacific Orthodontic Conference

TMD.第八届亚太正畸会议现状

• 发表时间: 2012
• 作者: Y Taguchi;S Yamasaki;H Mukasa;A Shimamoto;H Tahara;T Okamoto;Tanne K
• 通讯作者: Tanne K

Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow

流体流动调节滑膜细胞中透明质酸和浅表区蛋白的合成

• 发表时间: 2013
• 期刊: Eur J Oral Sci
• 影响因子: 1.9
• 作者: Tamami Yanagida-Suekawa;Kotaro Tanimoto;Yuki Tanne;Tomomi Mitsuyoshi;Naoto Hirose;Shaoching Su;Kazuo Tanne and Eiji Tanaka
• 通讯作者: Kazuo Tanne and Eiji Tanaka

Modulation of PRG4 expression by hyaluronan through CD44 receptor and ERK

透明质酸通过 CD44 受体和 ERK 调节 PRG4 表达

• 发表时间: 2013
• 作者: Yamasaki S;Nabeshima K;Sotomaru Y;Taguchi Y;Mukasa H;Furue MK;Sato JD;Okamoto T;Mitsuyoshi T
• 通讯作者: Mitsuyoshi T