Analysis of the mechanism for invasive ability by MUC16 and mesothelin in the pancreatic cancer.

MUC16与间皮素在胰腺癌侵袭能力的机制分析

• 批准号: 24890208
• 负责人: SHIMIZU Atsushi
• 金额: $ 2万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890208/
• 关键词: 膵癌浸潤規定遺伝子; MUC16; mesothelin; 膵癌; 浸潤能規定因子; 新規膵癌治療標的分子; 膵癌新規治療標的分子

We have identified two specific genes, MUC16 and mesothelin, associated with the invasion process in patients with pancreatic cancer using genome-wide expression profiling (Cancer Sci, 2012). In this study, it was intended to elucidate the mechanism of the invasion and metastasis, associated with EMT, induced by MUC16/mesothelin. By in vitro examination using pancreatic cancer cell line, it was suggested that the presence (and binding) of MUC16 and mesothelin in pancreatic cancer might affect the acquisition of high invasion and metastasis ability through the EMT. MUC16 and mesothelin clinically represent new prognostic biomarkers for PDAC and might be new therapeutic targets for patients with PDAC.

我们已经使用全基因组表达谱鉴定了与胰腺癌患者的侵袭过程相关的两种特异性基因MUC 16和间皮素（Cancer Sci，2012）。本研究旨在阐明MUC 16/mesothelin诱导EMT相关的侵袭转移机制。通过使用胰腺癌细胞系的体外检测，提示胰腺癌中MUC 16和间皮素的存在（和结合）可能通过EMT影响高侵袭和转移能力的获得。MUC 16和间皮素在临床上代表了PDAC的新的预后生物标志物，并可能成为PDAC患者的新的治疗靶点。

项目成果

膵癌における浸潤およびリンパ節転移関連遺伝子を用いた新規治療戦略

利用与胰腺癌侵袭和淋巴结转移相关的基因的新治疗策略

• 发表时间: 2013
• 作者: Ikura Y;Iwai Y;Muragaki Y;清水敦史
• 通讯作者: 清水敦史

網羅的遺伝子発現解析を用いた新規膵癌治療標的遺伝子の同定

利用综合基因表达分析鉴定新型胰腺癌治疗靶基因

• 发表时间: 2013
• 作者: 清水敦史;廣野誠子,谷眞至,川井学,岡田健一;宮澤基樹,北畑裕司,山上裕機
• 通讯作者: 宮澤基樹,北畑裕司,山上裕機

The specific genes related to the invasion process in pancreatic cancer, as demonstrated by genome-wide expression profiling-the role of MUC16 and mesothelin.

全基因组表达谱证明与胰腺癌侵袭过程相关的特定基因——MUC16和间皮素的作用。

• 发表时间: 2012
• 作者: Shimizu A;Hirono S;Tani M;Kawai M;Okada K;Miyazawa M;Kitahata Y;Nakamura Y;Noda T;Yokoyama S;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Yamaue H;Tani M;Hirono S;Hirono S;Okada K;Okada K;Miyazawa M;Miyazawa M;Shimizu A
• 通讯作者: Shimizu A