Application of MPC (basic study) for development of antibacterial denture surface

MPC（基础研究）在抗菌义齿表面开发中的应用

• 批准号: 24890238
• 负责人: TAKAHASHI Nana
• 金额: $ 1.91万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890238/
• 关键词: MPC; 義歯; デンチャープラーク; 歯学; MPC polymer; denture base resin; anti-biofilm formation; surface modification

MPC polymers have significant biocompatibility, are highly resistant to cell adhesion, and do not react with multiproteins. We have been studying for development of "the anti-adhesive denture" unattached dental plaque by MPC coating to denture surface. Previously, we have tested MPC coating on the dentures by using graft polymerization method, which have superior durability. However, we have found operability problem on this method. So, we examined the new method such as coating of contents mixed 2-HEMA and MPC, and of PMBPAz polymer copolymerized MPC and BMA. At the moment, we have reached clinical study with the PMBMAz polymer coating.

MPC聚合物具有显著的生物相容性，高度抵抗细胞黏附，不与多蛋白反应。我们一直在研究通过在义齿表面涂覆MPC来开发“防粘附着性义齿”的无附着菌斑。此前，我们用接枝聚合的方法在义齿上测试了MPC涂层，这种涂层具有更好的耐久性。然而，我们发现这种方法存在可操作性问题。为此，我们研究了2-HEMA和MPC混合包覆以及PMBPAz聚合物共聚合MPC和BMA的新方法。目前，我们已经完成了PMBMAz聚合物涂层的临床研究。

项目成果

EVALUATION OF THE DURABILITY AND ANTIADHESIVE ACTION OF 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE GRAFTING ON AN ACRYLIC RESIN DENTURE BASE MATERIAL

• DOI: 10.1016/j.prosdent.2013.08.020
• 发表时间: 2014-08-01
• 期刊: JOURNAL OF PROSTHETIC DENTISTRY
• 影响因子: 4.6
• 作者: Takahashi, Nana;Lwasa, Fuminori;Baba, Kazuyoshi
• 通讯作者: Baba, Kazuyoshi