The roles of Nup88-protein interaction in metastasis and invasion of cancer cells.

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It has been unclear whether Nup88 overexpression contributes to the malignant progression of cancer. In this study, we screened Nup88-binidng proteins and examined the effects of the interaction on cancer progression. Using an immunoprecipitation technique, we identified vimentin, a marker for epithelial-mesenchymal transformation, as a novel binding partner for Nup88. Vimentin expression at the protein level was unaffected by Nup88 overexpression and vice versa. Nup88 interacted with the N-terminal region of vimentin and the interaction kept vimentin monomeric. Since monomeric vimentin was reported to work as a transcriptional factor, we assume that Nup88 overexpression induces cancer malignancy via modulating the vimentin-regulated gene transcription.