Superconducting FT-NMR-Spectrometer 700 MHz

超导 FT-NMR 光谱仪 700 MHz

• 批准号: 455080901
• 金额: --
• 依托单位: Justus-Liebig-Universität Gießen
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/455080901?language=en
• 关键词: Superconducting; FT; NMR; Spectrometer; 700

High-resolution NMR spectroscopy is one of the most important modern analytical instruments in chemistry. There is currently an urgent need for action in this area at the Justus Liebig University to acquire a modern 700 MHz NMR spectrometer with an N2-cooled probe head, to improve the currently insufficient detection sensitivity when measuring small amounts from synthesis and natural product isolation and when measuring less sensitive hetero-nuclei with small amounts of substance. The NMR department of the Institute of Organic Chemistry is the only department of its kind within the university and is therefore responsible for all measurements, including those from related fields. Access to high-performance NMR analysis is essential for many working groups, for whom NMR spectroscopy is of central importance. At the moment, the sensitivity and resolution of our largest NMR spectrometer (600 MHz) are only conditionally sufficient to carry out the structure elucidation of the smallest amounts of substances and poorly soluble compounds. In particular, the probe head configuration of our largest NMR spectrometer, a 5 mm broadband probe head with automatic tuning (ATM, 13 years old and often in need of repair) and a 5 mm triple resonance inverse probe head without automatic tuning is too insensitive for the investigation of small amounts and analyses of natural product isolates. Also, suppression of solvents and lengthening of measuring times are not efficient enough for a complete structural analysis of very small quantities. A 700 MHz NMR spectrometer with an N2-cooled probe head would allow, due to its higher resolution and sensitivity, the smallest amounts of substances and poorly soluble compounds to be investigated, which can only be processed inadequately with the available equipment. The requested device is also of crucial importance for the maintenance and expansion of our competencies in the field of NMR structure analysis, also beyond the institutes in chemistry. The life sciences profile area of the Justus-Liebig University is to be expanded and supported through further development and cooperation with strong partners. For instance, the aim of "Insect Biotechnology" as an innovative and future-oriented research field of the Justus Liebig University and the new project group "Bioresources" is to identify new active substances in domestic insects that are used in medicine, crop protection or in food biotechnology. In this context, the requested 700 MHz NMR spectrometer enables us to work on new research areas and thus create the basis for further cooperation within and outside the university, which greatly increases the competitiveness of the Justus Liebig University in the field of structural analysis.

高分辨率核磁共振波谱是现代化学中最重要的分析仪器之一。目前，Justus Liebig大学迫切需要在这一领域采取行动，获得一台配备n2冷却探头的现代化700 MHz核磁共振光谱仪，以改善目前在测量合成和天然产物分离的少量以及测量少量物质的不太敏感的异核时不足的检测灵敏度。有机化学研究所的核磁共振系是该大学内唯一的核磁共振系，因此负责所有测量，包括来自相关领域的测量。获得高性能核磁共振分析对许多工作组来说是必不可少的，对他们来说核磁共振波谱是至关重要的。目前，我们最大的核磁共振光谱仪（600 MHz）的灵敏度和分辨率仅有条件地足以进行少量物质和难溶性化合物的结构解析。特别是，我们最大的核磁共振光谱仪的探头配置，一个带有自动调谐的5毫米宽带探头（ATM，已有13年历史，经常需要维修）和一个没有自动调谐的5毫米三共振反向探头，对于少量天然产物分离物的调查和分析太不敏感。此外，抑制溶剂和延长测量时间不足以有效地进行非常小数量的完整结构分析。700兆赫的核磁共振波谱仪配有氮气冷却探头，由于其更高的分辨率和灵敏度，可以研究最少量的物质和难溶化合物，这些物质和难溶化合物只能用现有设备进行处理。所要求的设备对于维持和扩大我们在核磁共振结构分析领域的能力也至关重要，也超出了化学研究所。尤斯图斯-李比希大学的生命科学领域将通过与强大的合作伙伴的进一步发展和合作来扩大和支持。例如，“昆虫生物技术”作为尤斯图斯·李比希大学和新项目小组“生物资源”的一个创新和面向未来的研究领域，其目标是确定国内昆虫中用于医药、作物保护或食品生物技术的新活性物质。在这种情况下，所要求的700 MHz核磁共振光谱仪使我们能够在新的研究领域开展工作，从而为大学内外的进一步合作奠定基础，这大大提高了Justus Liebig大学在结构分析领域的竞争力。