Superconducting FT-NMR-Spectrometer 700 MHz

高分辨核磁共振波谱是现代化学中最重要的分析仪器之一。贾斯图斯·利比格大学目前迫切需要在这一领域采取行动，以获得一台带有氮气冷却探头的现代700兆赫核磁共振波谱仪，以提高目前在测量合成和天然产物分离的少量以及在测量具有少量物质的不太灵敏的异核时的探测灵敏度。有机化学研究所的核磁共振系是该大学内唯一的这类系，因此负责所有测量，包括相关领域的测量。对于许多工作组来说，获得高性能的核磁共振分析是必不可少的，核磁共振波谱对他们来说是至关重要的。目前，我们最大的核磁共振波谱仪(600 MHz)的灵敏度和分辨率仅有条件地足以进行最少量的物质和难于溶解的化合物的结构鉴定。特别是，我们最大的核磁共振光谱仪的探头配置，一个带有自动调谐的5 mm宽带探头(ATM，已有13年历史，经常需要维修)和一个没有自动调谐的5 mm三共振反向探头对于少量研究和天然产品分离的分析来说太不敏感了。此外，抑制溶剂和延长测量时间对于非常少量的完整结构分析来说是不够有效的。一台带有氮气冷却探头的700兆赫核磁共振光谱仪，由于其较高的分辨率和灵敏度，将允许研究最少量的物质和难溶化合物，而这些物质和化合物只能用现有的设备进行不充分的处理。所要求的设备对于保持和扩大我们在核磁共振结构分析领域的能力也是至关重要的，这也超出了化学研究所的范围。JUSTUS-LIEBIG大学的生命科学概况领域将通过进一步发展和与强大的合作伙伴合作来扩大和支持。例如，贾斯图斯·利比希大学和新的项目组“生物资源”将“昆虫生物技术”作为一个创新的、面向未来的研究领域，其目的是在用于医药、作物保护或食品生物技术的家养昆虫中识别新的活性物质。在这种情况下，所要求的700兆赫核磁共振波谱仪使我们能够在新的研究领域开展工作，从而为大学内外的进一步合作奠定了基础，这大大提高了贾斯图斯·利比希大学在结构分析领域的竞争力。

High-resolution NMR spectroscopy is one of the most important modern analytical instruments in chemistry. There is currently an urgent need for action in this area at the Justus Liebig University to acquire a modern 700 MHz NMR spectrometer with an N2-cooled probe head, to improve the currently insufficient detection sensitivity when measuring small amounts from synthesis and natural product isolation and when measuring less sensitive hetero-nuclei with small amounts of substance. The NMR department of the Institute of Organic Chemistry is the only department of its kind within the university and is therefore responsible for all measurements, including those from related fields. Access to high-performance NMR analysis is essential for many working groups, for whom NMR spectroscopy is of central importance. At the moment, the sensitivity and resolution of our largest NMR spectrometer (600 MHz) are only conditionally sufficient to carry out the structure elucidation of the smallest amounts of substances and poorly soluble compounds. In particular, the probe head configuration of our largest NMR spectrometer, a 5 mm broadband probe head with automatic tuning (ATM, 13 years old and often in need of repair) and a 5 mm triple resonance inverse probe head without automatic tuning is too insensitive for the investigation of small amounts and analyses of natural product isolates. Also, suppression of solvents and lengthening of measuring times are not efficient enough for a complete structural analysis of very small quantities. A 700 MHz NMR spectrometer with an N2-cooled probe head would allow, due to its higher resolution and sensitivity, the smallest amounts of substances and poorly soluble compounds to be investigated, which can only be processed inadequately with the available equipment. The requested device is also of crucial importance for the maintenance and expansion of our competencies in the field of NMR structure analysis, also beyond the institutes in chemistry. The life sciences profile area of the Justus-Liebig University is to be expanded and supported through further development and cooperation with strong partners. For instance, the aim of "Insect Biotechnology" as an innovative and future-oriented research field of the Justus Liebig University and the new project group "Bioresources" is to identify new active substances in domestic insects that are used in medicine, crop protection or in food biotechnology. In this context, the requested 700 MHz NMR spectrometer enables us to work on new research areas and thus create the basis for further cooperation within and outside the university, which greatly increases the competitiveness of the Justus Liebig University in the field of structural analysis.