500 MHz FT-NMR spectrometer

500 MHz 傅里叶变换核磁共振波谱仪

• 批准号: 510821619
• 金额: --
• 依托单位: Universität Bielefeld
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/510821619?language=en
• 关键词: 500; MHz; FT; NMR; spectrometer

NMR spectroscopy has become a valuable and extremely useful analytical tool not only in the field of chemistry. To answer scientific questions about the structure and reactivity of molecules in solution, this method is absolutely essential. The instrument, which is the subject of the present application, is available to all work groups of the faculty. However, within the faculty it is mainly used by the synthetically oriented work groups of organic and inorganic chemistry. The scientific topics and issues addressed here are consequently multifaceted. They range from catalysis – enantioselective utilizing bio catalysts or metal-based catalytically active systems – to the analyses of peptide conformations and peptide-protein interactions, the structural elucidation of ethnomedical agents extracted from plant sources – obtained very often only on a submilligram scale – to the study of weak intra- and intermolecular donor-acceptor interactions insolution as well as complex formation of poly-Lewis acids. Almost all of these research topics require NMR measurements with suitable spectral resolution and sensitivity, which are sometimes very time consuming, to elucidate structures and reaction pathways. Renewal of the old spectrometer is intended to ensure the operational capability for another 10 – 15 years, and also offer the possibility to implement current pulse sequences. The instrument requested is to provide both by its field strength, and it is to guarantee that all users will have sufficient measurement time over the next 10 – 15 years to perform timely and efficient NMR measurements on their samples, which are produced in high numbers in the synthesis laboratories.

核磁共振波谱不仅在化学领域已成为一种有价值且极其有用的分析工具。为了回答有关溶液中分子的结构和反应性的科学问题，这种方法是绝对必要的。该仪器是本申请的主题，可供教师的所有工作组使用。然而，在学院内部，它主要由有机和无机化学的综合工作组使用。因此，这里讨论的科学主题和问题是多方面的。它们的范围从催化——利用生物催化剂或金属催化活性系统的对映选择性——到肽构象和肽-蛋白质相互作用的分析，从植物来源提取的民族医学制剂的结构阐明——通常只能在亚毫克规模上获得——到研究溶液中弱的分子内和分子间供体-受体相互作用以及复杂的形成 聚路易斯酸。几乎所有这些研究主题都需要具有适当光谱分辨率和灵敏度的核磁共振测量，有时非常耗时，以阐明结构和反应途径。旧光谱仪的更新旨在确保另外 10-15 年的运行能力，并提供实施电流脉冲序列的可能性。所要求的仪器既要提供场强，又要保证所有用户在未来 10 - 15 年里有足够的测量时间，对合成实验室大量生产的样品进行及时有效的 NMR 测量。