DEVELOPMENT OF HYBRID-TYPE LANTHANIDE COMPLEXES AS EFFECTIVE RECEPTORS

杂化型镧系元素配合物作为有效受体的开发

• 批准号: 10440198
• 负责人: TSUKUBE Hiroshi
• 金额: $ 2.5万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10440198/
• 关键词: Lanthanide Complex; Amino Alcohol; Amino Acid; CD Probe; Chirality; CD Spectrum; Molecular Recognition; キラル・センシング; 不斉センシング; 液-液抽出; レセプター; CD

A series of lanthanide tris (β-diketonates) and porphyrinates were developed as effective receptors of chiral biological substrates. These lanthanide complexes are electrically neutralized by coordinating ligands but formed highly coordinated 1 : 1 complexes with various substrates. We successfully optimized the combinations of coordinating ligands and lanthanide centers to realize specific recognition and sensing of non-chromophoric chiral biological substrates. Two types of specific receptors were developed based on lanthanide coordination chemistry : (1) Lanthanide tris (fluorinated β-diketonates) provided highly efficient fluorescence and CD sensing of chiral amino alcohols ; (2) Additional functionalization of lanthanide porphyrinates gave highly sensitive CD probes for multi-functional biogenetic amine and dipeptides. Since there are wide structural variations in the design of lanthanide complexes, new aspects of lanthanide coordination chemistry revealed in this study can offer promising possibilities in developing a new series of recognition and sensing systems involving intelligent lanthanide complexes.

一系列镧系三（β-二酮）和卟啉配合物被开发为手性生物底物的有效受体。这些镧系元素配合物被配位配体电中和，但与各种底物形成高度配位的1：1配合物。我们成功地优化了配位体和镧系中心的组合，实现了对非发色手性生物底物的特异性识别和传感。基于镧系元素配位化学，开发了两种类型的特异性受体：（1）镧系三（氟化β-二酮）配合物提供了高效的荧光和手性氨基醇的CD传感;（2）镧系卟啉配合物的额外功能化提供了高灵敏度的多功能生物胺和二肽的CD探针。由于在镧系元素配合物的设计中存在广泛的结构变化，因此本研究揭示的镧系元素配位化学的新方面可以为开发一系列涉及智能镧系元素配合物的新的识别和传感系统提供有前途的可能性。

项目成果

H.Tsukube 他: "Porphyrinatoerbium-Crown Ether Conjugate for synergistic Binding and Chirality Sensing of Zuitteraonic Amino Acids"Chem.Commun.. 1007-1008 (1999)

H. Tsukube 等人：“用于 Zuitteraonic 氨基酸的协同结合和手性传感的卟啉铒-冠醚缀合物”Chem.Commun.. 1007-1008 (1999)

H.Tsukube 他: "Conjugate Strategy of Lanthanide Porphyrinate with Crown Ether Toward Synergistic Binding and Chirality Sensing of Biological Substrates"J.Alloys.Comp.. (印刷中). (2001)

H. Tsukube 等人：“镧系卟啉与冠醚的共轭策略促进生物底物的协同结合和手性传感”J. Alloys。（出版中）。

H.Tamiaki 他: "Induced Circular Dichroism Active Completes of Synthetic Gadolinium Porphyrinates with Chiral Amins Acids"Inorg.Chim.Acta. 300. 243-249 (2000)

H. Tamiaki 等人：“合成卟啉钆与手性氨基酸的诱导圆二色性活性完成”Inorg.Chim.Acta 300. 243-249 (2000)

H.Tsukube et al.: ""Conjugate Strategy" of Lanthanide Porphyrinate with Crown Ether Toward Synergistic Binding and Chirality Sensing of Biological Substrates"J.Alloys.Comp.. (in press).

H.Tsukube 等人：“镧系卟啉与冠醚的“共轭策略”实现生物底物的协同结合和手性传感”J.Alloys.Comp..（出版中）。

H.Tamiaki et al.: "Induced Circular Dichroism Active Complexes of Synthetic Gadolinium Porphyrinates with Chiral Amino Acids"Inorg.Chim.Acta. 300. 243-249 (2000)

H.Tamiaki 等：“合成卟啉钆与手性氨基酸的诱导圆二色活性复合物”Inorg.Chim.Acta。