SYNTHESIS OF RECEPTOR MOLECULES VIA NEW CHEMICAL METHODS

通过新的化学方法合成受体分子

• 批准号: 08454205
• 负责人: TSUKUBE Hiroshi
• 金额: $ 3.46万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08454205/
• 关键词: Ion Recognition; Computer Chemistry; Biocatalyst; Armed Cyclen; Anion receptor; アームド・マクロサイクル; 分子設計; ホスト分子

Since "molecular recognition" plays important roles in biomembrane transport, enzymatic reactions, and other biological processes, synthesis of specific receptors is one of the most exciting subjects in current chemistry. They offer excellent opportunities in investigating biological functions and developing supermolecular devices.Although many kinds of artificial receptors have been presented, their design and synthesis are "trial-and-error" exercises. We developed in this project non-empirical design and highly efficient synthesis of specific receptors as summarized below :(1)Computational Design of Cation-Specific Receptor : We optimized Na^+ ion-specific armed macrocycles by computational modeling.(2)Efficient Synthesis of Chiral Pyridine Podands : A combined synthesis with biocatalysts and organometallics offered a new series of chiral oligopyridine ligands in excellent yields.(3)One-Step Synthesis of Anion-Specific Receptors : A new type of macrocycle containing four pyridinium cations was readily prepared, which exhibited highly selective anion binding functions.

由于“分子识别”在生物膜运输、酶促反应和其他生物过程中起着重要作用，因此特异性受体的合成是当前化学中最令人兴奋的课题之一。尽管人工受体的种类很多，但其设计和合成都是“反复试验”的过程。本项目主要开展了非经验设计和高效合成特异性受体的研究工作，主要内容如下：（1）阳离子特异性受体的计算设计：通过计算机模拟优化了Na^+离子特异性武装大环化合物。（2）手性吡啶配体的高效合成：生物催化剂和有机金属化合物的联合合成以优异的产率提供了一系列新的手性寡吡啶配体。（3）阴离子特异性受体的一步合成：合成了一种新型的含四个吡啶阳离子的大环化合物，它具有高选择性的阴离子结合功能。

项目成果

Hiroshi Tsukube 他: "Enhanced Li^+ Ion-Selective Ionophoric Properties of Double Armed Diaza-12-Crown-4 Derivetives" Tetrahedron. 53. 3487-3496 (1997)

Hiroshi Tsukube 等人：“双臂 Diaza-12-Crown-4 衍生物的增强 Li^+ 离子选择性离子传递特性”四面体 53. 3487-3496 (1997)

Hiroshi Tsukube: "Na^+ Ion-Selective Binding and Extraction by Lipophilic Armed Cyclens via Octadertate Encapsulation" Tetrahedron Letters. 38. 5021-5024 (1997)

Hiroshi Tsukube：“通过八角形封装通过亲脂性武装循环进行 Na^ 离子选择性结合和提取”四面体字母。

H.Tsukube et al.: "Na^+ Ion-Selective Binding and Extraction by Lipophilic Armed Cyclens via Octadentate Encapsulation" Tetrahedron Letters. 38. 5021-5024 (1997)

H.Tsukube 等人：“通过八齿封装通过亲脂性武装循环进行 Na^ 离子选择性结合和提取”四面体字母。

H. Tsukube, S. Shinoda: "Computer-Aided Design of Metal Ion-Specific Carriers for Liquid Membrane Separation" Proceedings of 1996 Annual Mambrane Technology/Separation planning Conference. (印刷中).

H. Tsukube、S. Shinoda：“用于液体膜分离的金属离子特异性载体的计算机辅助设计”1996 年年度膜技术/分离规划会议记录（正在出版）。

H.Tsukube et al.: "Enhanced Li^+ Ion-Selective Ionophoric Properties of Double-Armed Diaza-12-Crown-4 Derivatives" Tetrahedron. 53. 3487-3496 (1997)

H.Tsukube 等人：“双臂 Diaza-12-Crown-4 衍生物的增强 Li^ 离子选择性离子传递特性”四面体。