Hemodynamic analysis and efficient control of ischemic heart in chronically instrumented dogs

长期使用仪器的狗的血流动力学分析和缺血性心脏的有效控制

• 批准号: 10470319
• 负责人: SUMIKAWA Koji
• 金额: $ 8.06万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470319/
• 关键词: anesthetics; hemodilution; chronic instrumented dog; ischemia; K_<ATP> channel; stunned myocardium; P-V loop; reperfusion injury; 慢性装置埋込犬; 心筋虚血; 血行動態; イソフルラン; セボフルラン; プレコンディショニング; 吸入麻酔薬; ATP感受性カリウムチャネル; 虚血・再潅流障害; カリウムチャネル開口薬; カリウムチャネル遮断薬

This study was carried out to establish the model of stunned myocardium with chronically instrumented dogs, and to analyze systemic and coronary hemodynamics under administration of several anesthetics and vasoactive drugs using the computer-based cardiovascular measurement system including the analysis of left ventricular pressure-volume relationship.The direct effects of several anesthetics on myocardial contractility were studied. The, direct myocardial depressant effect of etomidate, ketamine and propofol was dose dependent. Fentanyl had no negative inotropic effect. The hemodynamic actions of kromakalim were studied under the conscious state and during isoflurane anesthesia. The coronary vasodilating effects of isoflurane and cromakalim were basically additive until cromakalim exerted the maximal effects. The combined effects of dantrolen with propofol on the systemic and coronary hemodynamics were studied. A clinical dose of dantrolen reversed the decrease in heart rate, coronary … More blood flow and mean arterial pressure caused by propofol anesthesia.The hemodynamic and cardioprotective effects of sevoflurane in stunned myocardium were studied. Sevoflurane had a cardioprotective effect mediated through activation of mitochondria! K^ channels. The efficacy of MQ-154 after sevoflurane anesthesia for myocardial contractile function and oxygen consumption on stunned myocardium were studied. The combination of low-dose MCI-154 with sevoflurane could synergisucally act to produce full recovery of myocardial contraction without increase in myocardial oxygen consumption and heart rate after ischemia/reperfusion.The effects of sevoflurane on myocardial contractility and systemic and coronary hemodynamics, as compared with the effects of isoflurane under the same cardiac work condition, were studied. Myocardial depressant effects were comparable between sevoflurane and isoflurane, and both systemic and coronary vasodilatory effects of isoflurane were greater than those of sevoflurane. The cardiovascular effects of sevoflurane under acute normovolemic hemodilution were studied. Acute normovolemic hemodilution was beneficial during sevoflurane anesthesia with respect to the left ventricular-arterial coupling and mechanical efficiency. Less

本研究建立了犬顿抑心肌模型，应用计算机心血管测量系统，分析了几种麻醉药和血管活性药物对犬全身和冠状动脉血流动力学的影响，包括左心室压力-容积关系的分析，并探讨了几种麻醉药对心肌收缩力的直接影响。依托咪酯、氯胺酮和丙泊酚的直接心肌抑制作用呈剂量依赖性。芬太尼无负性肌力作用。本文研究了在清醒状态下和异氟醚麻醉时克罗卡林的血流动力学作用。异氟烷和色满卡林的冠状动脉血管扩张作用基本上是相加的，直到色满卡林发挥最大作用。观察丹曲伦与异丙酚合用对全身及冠状动脉血流动力学的影响。临床剂量的丹曲伦逆转了心率、冠状动脉 ...更多信息 观察七氟醚对顿抑心肌血流动力学及心肌保护作用。七氟烷具有通过激活线粒体介导的心脏保护作用！K^通道。观察MQ-154对七氟醚麻醉后顿抑心肌收缩功能和氧耗的影响。本文研究了七氟醚与小剂量MCI-154联合应用对缺血/再灌注后心肌收缩功能的影响，并与异氟醚在相同心脏作功条件下对心肌收缩功能、全身和冠状动脉血流动力学的影响进行了比较。七氟烷和异氟烷的心肌舒张作用相当，异氟烷的全身和冠状血管舒张作用均大于七氟烷。本文研究了七氟醚在急性等容血液稀释条件下的心血管效应。急性等容血液稀释在七氟烷麻醉期间有利于左心室-动脉耦合和机械效率。少

项目成果

Hara T, Tomiyasu S, Hasuo H, Ureshino Y, Sumikawa K: "Cardioprotective effects of a novel KATP channel opener, JTV506, in stunned myocardium in dogs"Anesthesiology. 89. A607 (1998)

Hara T、Tomiyasu S、Hasuo H、Ureshino Y、Sumikawa K：“新型 KATP 通道开放剂 JTV506 对犬心肌顿抑的心脏保护作用”麻醉学。

Tomiyasu S, Hara T, Hasuo H, Sumikawa K: "Vasopressin antagonist improves functional recovery of stunned myocardium in dogs"Anesthesiology. 89. A610 (1998)

Tomiyasu S、Hara T、Hasuo H、Sumikawa K：“加压素拮抗剂可改善狗致昏心肌的功能恢复”麻醉学。

Sumikawa K, Zhang S, Sakai K, Hasuo H, Shibata O: "Hemodynamic interaction of dantrolene and propofol in chronically instrumented dogs"Anesthesiology. 91. A661 (1999)

Sumikawa K、Zhang S、Sakai K、Hasuo H、Shibata O：“长期使用仪器的狗中丹曲林和丙泊酚的血流动力学相互作用”麻醉学。

Sakai K, Zhang, Ureshio H, Tomiyasu S, Sumikawa K: "Interaction of isoflurane and cromakalim, a K-ATP channel opener, on coronary and systemic haemodynamics in chronically instrumented dogs"Acta Anaesthesiologica Scandinavica. 44. 1122-1127 (2000)

Sakai K、Zhang、Ureshio H、Tomiyasu S、Sumikawa K：“异氟烷和 Cromakalim（一种 K-ATP 通道开放剂）对长期使用仪器的狗的冠状动脉和全身血流动力学的相互作用”Acta Anaesthesiologica Scandinavica。

Hara T,Tomiyasu S,et al.: "Cardioprotective effects of a novel KATP channel opener,JTV506,in stunned myocardium in dogs." Anesthesiology. 89・3A. A607 (1998)

Hara T、Tomiyasu S 等人：“新型 KATP 通道开放剂 JTV506 对狗的心肌损伤的保护作用”89·3A607。