Hemodynamic Interactions of Anesthetics and K Channel Openers in Chronically Instrumented Dogs

长期接受仪器治疗的狗中麻醉药和 K 通道开放剂的血流动力学相互作用

• 批准号: 07457359
• 负责人: SUMIKAWA Koji
• 金额: $ 4.93万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457359/
• 关键词: Chronically Instrumented Dog; Anesthetics; Potassium Channels; Hemodynamics; Coronary Hemodynamics; Sevoflurane; Isoflurane; カリウムチャネル開口薬

The present study was carried out to determine the hemodynamic interactions of KATP channel openers and anesthetics in chronically instrumented dogs.Dogs were chronically instrumented to measure mean arterial pressure (MAP), heart rate (HR), left circumflex coronary blood flow (CBF), cardiac output (CO), and regional contractile function (%SS). Hemodynamics were measured continuously in the conscious state or during anesthesia.The KATP channel openers, cromakalim, nicorandil and JTV-506, were shown to have selectively potent effect on coronary vasodilation. The effects of coronary vasodilation caused by isoflurane and sevoflurane were completely abolished by a KATP channel closer, glibenclamide, suggesting that the activity of KATP channels might contribute the mechanism underlying volatile anesthetics on vasodilation. Isoflurane enhances the vasodilating action of cromakalim on both systemic and coronary vasculature and attenuates the cromakalim-induced increases in CO and myocardial contractility. The results also suggest that when the pharmacology of KATP channel openers are studied in animals, the effect of anesthetics should be excluded. The experiment of arrhythmias indicated that Ito but not KATP channels might be involved in the mechanism in producing halothane-epinephrine arrhythmias.

本研究旨在探讨KATP通道开放剂和麻醉剂在慢性内固定犬中的血流动力学相互作用，通过测量犬的平均动脉压（MAP）、心率（HR）、左回旋支冠脉血流量（CBF）、心输出量（CO）和局部收缩功能（%SS）来研究KATP通道开放剂和麻醉剂的血流动力学相互作用。KATP通道开放剂色满卡林、尼可地尔和JTV-506对冠状动脉有选择性舒张作用。异氟烷和七氟烷引起的冠状动脉血管舒张作用可被KATP通道封闭剂格列本脲完全消除，这表明KATP通道的活性可能是挥发性麻醉剂舒张血管的潜在机制。异氟烷可增强色满卡林对全身和冠状动脉血管的舒张作用，并减弱色满卡林诱导的CO和心肌收缩力增加。结果还表明，当在动物中研究KATP通道开放剂的药理学时，应排除麻醉剂的作用。心律失常实验表明，Ito通道可能参与了氟烷-肾上腺素心律失常的发生机制，而KATP通道可能不参与。

项目成果

Zhang S,Sumikawa K,Ureshino H,Tomiyasu S,Shibata O: "Comparative Effects of KATP Channel Opener, Nicorandil, JTV506 and Cromakalim, on Systemic and Coronary Hemodynamics in Chronically Instrumented Dogs" Anesthesiology. 87 (3). A606 (1997)

张 S，Sumikawa K，Ureshino H，Tomiyasu S，Shibata O：“KATP 通道开放剂、尼可地尔、JTV506 和 Cromakalim 对慢性仪器犬全身和冠状动脉血流动力学的比较影响”麻醉学。

Sumikawa K: "Comparative Effects of KATP Channel Openers on Systemic and Coronary Hemodynamics in Chronically Instrumented Dogs" Abstract Book of 10th Asian Australasian Congress of Anaesthesiologists.FE4. (1998)

Sumikawa K：“KATP 通道开放剂对慢性仪器犬全身和冠状动脉血流动力学的比较影响”第 10 届亚洲澳大利亚麻醉医师大会摘要书。FE4。

Zhang S, Hasuo H, et al.: "Effect of JTV506, a novel ATP-sensitive potassium channel opener on systemic and coronary hemodynamics in chronically instrumented dogs" Anesthesiology. 87・3. A546 (1997)

张 S、Hasuo H 等人：“JTV506（一种新型 ATP 敏感钾通道开放剂）对长期使用仪器的狗的全身和冠状动脉血流动力学的影响”麻醉学 87·3。

Sakai K,Zhang S,Tomiyasu S,Ureshino H,Sumikawa K: "Interaction of KATP Channel Opener and Isoflurane on Systemic and Coronary Hemodynamics" Anesthesiology. 89 (3). A611 (1998)

Sakai K，Zhang S，Tomiyasu S，Ureshino H，Sumikawa K：“KATP 通道开放剂和异氟烷对全身和冠状动脉血流动力学的相互作用”麻醉学。

Sumikawa K, Zhang S, et al.: "Role of ATP-sensitive potassium channel in systemic and coronary hemodynamic actions of isoflurane in chronically instrumented dogs" Anesth Analg. 84. S550 (1997)

Sumikawa K、Zhang S 等人：“ATP 敏感钾通道在异氟醚对长期仪器犬的全身和冠状动脉血流动力学作用中的作用”Anesth Analg。