Research on spectrotomography inside skin by supercontinuum white light

超连续谱白光皮肤内光谱断层成像研究

• 批准号: 10555017
• 负责人: ITOH Kazuyoshi
• 金额: $ 3.52万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10555017/
• 关键词: Ultrashort laser pulse; Supercontinuum; Self-phase modulation; Filament; Spatial coherence; Low-cohrence interferometery; Spectroscoppic tomography; Skin; 広帯域白色光パルス; 白色コンティニュアム光; アレイ化; 分光学的断層像

The purpose of this research work is to develop a method to generate stable supercontinuum white-light sources and to prove *e feasibility of reconstructing spectrotomographic images inside human skin using the supercontinuum white-light sources. The results obtained in the researchare listed below.1) Array of supercontinuum white-light sourcesTo generate stable supercontinuum white-light sources by using the Ti : Sapphire laser light, we attempted to generate an array of supercontinuum white-light sources by use of a microlens array and succeeded in generating approximately 100 supercontinuum white-light sources simultaneously. We also investigated the statistical characteristics of formation of the filaments that generate the supercontinuum white-light sources by time-resolved Schlieren-optics observation.2) Study of spatial coherence of supercontinuum white-lightThe optical coherence between the elementary sources in the array of supercontinuum white-light sources has been studied a … More nd extremely high spatial coherence was measured. We also showed experimentally that the high spatial coherence between the lights generated in two filaments of the multiple filaments that are formed in the liquid and solid by a single beam of the Ti ; Sapphire ultrashort lasers pulses.3) SpectrotomographyWe built a non-dispersive and a dispersive coherence spectrotomography systems that measure simultaneously the spatial and spectral information inside the object. The systems make use of the supercontinuum white-light source as a light source. We evaluated the systems in terms of spatial resolution limit of layered media, spectral resolution, signal-to-noise ratio. The dispersive coherence spectrotomograpy system was evaluated by applying the system to small shrimps. We succeeded in obtaining clear spectrotomography image of the tail of shrimp. Due to the instability of supercontinuum white-light source, however, the application experiments to human skin could not committed.The results of this research were partly published (Optical Review ; 1999, Japanese Journal of Applied Physics ; 2001) and review papers were also published (Optical Review ; 2000, Japanese Journal of Optics ; 2000). The rest of the results are under preparation for publication. Less

这项研究工作的目的是开发一种产生稳定的超连续白光光源的方法，并证明使用超连续白光光源重建人体皮肤内的光谱层析图像的可行性。1)超连续白光源阵列为了利用钛宝石激光产生稳定的超连续白光源，我们尝试用微透镜阵列产生超连续白光源阵列，并成功地同时产生了近100个超连续白光源。用时间分辨纹影光学方法研究了产生超连续白光灯丝的统计特性。2)超连续白光空间相干性的研究。用…研究了超连续白光阵列中各基元之间的光学相干性测量了更多和极高的空间相干性。我们还在实验上证明了由单束钛在液体和固体中形成的多个细丝中的两个细丝产生的光之间的高度空间相干性；蓝宝石超短激光脉冲。3)光谱层析成像我们建立了一个非色散和色散相干光谱层析成像系统，可以同时测量物体内部的空间和光谱信息。该系统利用超连续白光光源作为光源。从层状介质的空间分辨率极限、光谱分辨率、信噪比等方面对系统进行了评价。将色散相干光谱成像系统应用于小对虾，对该系统进行了评价。我们成功地获得了对虾尾部的清晰光谱层析图像。但是，由于超连续白光光源的不稳定性，在人体皮肤上的应用实验无法进行。这项研究的部分成果发表了(《光学评论》，1999，《日本应用物理杂志》，2001)，也发表了一些综述论文(《光学评论》，2000，《日本光学杂志》；2000)。其余的结果正在准备发表中。较少

项目成果

渡辺歴,伊東一良: "干渉分光トモグラフィー"O plus E. 21・7. 857-862 (1999)

Kei Watanabe、Kazuyoshi Ito：“干涉光谱断层扫描”O plus E. 857-862 (1999)。

Wataru Watanabe: "Coherence spectrotomography using white-light continuum"Jpn.J.Opt. (KOGAKU). Vol.28, No.3. 143-144 (1999)

Wataru Watanabe：“使用白光连续谱的相干光谱分析”Jpn.J.Opt。

Wataru Watanabe: "Coherent array of white-light continuum generated by microlens array"Optical Review. 6・3. 167-172 (1999)

渡边渡：“微透镜阵列产生的白光连续相干阵列”光学评论 6・3（1999）。

Wataru Watanabe and Kazuyoshi Itoh: "Coherence spectrotomography : optical spectroscopic tomography with low-coherence interferometry"Opt.Rev.. Vol.7, No.5. 406-414 (2000)

Wataru Watanabe 和 Kazuyoshi Itoh：“相干光谱断层扫描：低相干干涉测量的光学光谱断层扫描”Opt.Rev.. Vol.7，No.5。

Wataru Watanabe: "Coherence spectrotomography of layered medium with white-light continuum"Optical Review. 6・1. 71-76 (1999)

Wataru Watanabe：“白光连续介质的相干光谱”光学评论 6・1（1999）。