权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Synthesis of apatite-organic polymer hybrid materials by chemical modification

化学改性合成磷灰石-有机聚合物杂化材料

基本信息

批准号：
10555217
负责人：
MINODA Masahiko
金额：
$ 7.04万
依托单位：
Kyoto Institute of Technology (2000)Kyoto University (1998-1999)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

In this research was investigated the synthesis of bonelike apatite-organic polymer hybrid materials via a biomimetic process in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma or a solution (1.5SBF) with ion concentrations 1.5 times those of SBF.Main results include :1. The surface of ethylene-vinyl alcohol copolymer substrates and knitted fibers were modified with silanol (Si-OH) groups by the reaction with a triethoxysilyl group-containing silane coupling agent and the subsequent hydrolysis and polycondensation of tetraethoxysilane. The silanol-modified specimens were found to form apatite layer on them within a few weeks in 1.5SBF.Moreover, the specimens treated with calcium silicate solution can form apatite within a few days even in SBF, indicating introduction of calcium ions into the surface silicate layer brings about the enhanced apatite-forming ability.2. It was found that the gels prepared from carboxymethyl (CM) cellulose, CM-chitin and gellan gum, all of which possess carboxylate functions, formed apatite on their surfaces within 3 days in SBF, when they were previously treated with a saturated Ca(OH)_2 solution. Calcium alginate gels and fibers originally having carboxyl groups and calcium ions also formed apatite on them within a week in SBF.These results indicate that the carboxylate groups on the gels are effective for the apatite nucleation and the apatite forming ability of the polymer can be improved by incorporation of the calcium ions.In conclusion, various types of polymers were found to be promising candidates for obtaining apatite-polymer hybrids with bonelike structure through a combination of simple chemical modifications and biomimetic process.

本文研究了在离子浓度接近人体血浆的模拟体液(SBF)或离子浓度为SBF 1.5倍的溶液(1.5SBF)中仿生合成类骨磷灰石-有机聚合物杂化材料的方法。主要研究结果包括：1.通过含三乙氧基硅烷偶联剂的硅烷偶联剂和四乙氧基硅烷的水解缩聚反应，在乙烯-乙烯醇共聚物基材和针织纤维表面进行硅醇(Si-OH)基团的改性。在1.5SBF中，硅醇改性样品在几周内就能形成磷灰石层，而且，即使在SBF中，硅酸钙溶液处理的样品也能在几天内形成磷灰石，这表明钙离子的引入提高了表面硅酸盐层形成磷灰石的能力。研究发现，具有羧化功能的羧甲基(CM)纤维素、CM-甲壳素和结冷胶在SBF中经饱和Ca(OH)_2溶液处理后，在3d内即可在其表面形成磷灰石。在SBF中，原本含有羧基和钙离子的海藻酸钙凝胶和纤维在一周内也形成了磷灰石。这些结果表明，凝胶上的羧基对磷灰石的成核是有效的，钙离子的加入可以提高聚合物的磷灰石形成能力。综上所述，各种类型的聚合物通过简单的化学修饰和仿生过程相结合，是获得具有骨状结构的磷灰石-聚合物杂化材料的潜在候选者。