Using an online database to search for analytical method to detect poison

利用在线数据库寻找毒物检测分析方法

• 批准号: 10557047
• 负责人: KOJIMA Tohru
• 金额: $ 8.96万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557047/
• 关键词: Internet; e-mail list; poisoning information; analytical method; on line database; on line request system of analysis; データベース; 分析法; 薬物; 毒物

Inorder to quickly know the cause of a poisoning due to drugs or chemical hazards, information of clinical symptoms and analytical methods of poisons were collected, and an online database of the information and a request system for analysis were developed. The information was collected by using the following internet mailing lists : ml-poison and ml-anal. The information was divided into the following four groups.Group A : Simple detection method of poisons. Ten poisons of which intoxications occur very frequently were selected, and simple detection methods of them were listed.Group B : Database of verified analytical methods. Seven hundred analytical methods were selected by MEDLINE.The methods included extraction methods, analytical conditions, derivatization methods, detection limits, interpretation of concentrations in biological materials and information sources. Suitable methods were searched by using some key words such as 'compound name', 'sample matrix' and 'analytical method … More '.Group C : Recommended analytical methods. Analytical methods of detecton of poisons of which intoxications occur frequently were listed. They were translated into Japanese.Group D : Analytical methods used in laboratories of our members. Analytical methods used in laboratories of our members were listed.The information was arranged, and put on a web site : <http : //maple-www2.med.hiroshimau.ac.jp>. CD-ROMs containing the information were distributed to laboratories where internet access was unavailable.A request system for analysis was developed by using the internet. When a chemist is unable to analyze a poison in the laboratory, he or she can send a request to have it analyzed in another laboratory through the ml-poison list.This is a project in which all analytical laboratories in the field of legal medicine and other related fields in Japan will be connected through the internet. If this system works well, we can quickly know the cause of a poisoning due to drugs or chemical hazards. Less

为了快速了解药物或化学品中毒的原因，收集了中毒的临床症状和分析方法信息，并开发了信息在线数据库和分析请求系统。这些信息是通过以下互联网邮件列表收集的：ml-poison和ml-anal。这些信息被分为以下四组。A组：简易毒物检测法。选择了10种常见的中毒药物，并列举了它们的简易检测方法。B组：验证分析方法数据库。MEDLINE选择了700种分析方法。方法包括提取方法、分析条件、衍生化方法、检出限、生物材料浓度解释和信息源。通过“化合物名称”、“样品矩阵”、“分析方法”等关键词搜索合适的方法。C组：推荐的分析方法。列举了易引起中毒的毒物的分析检测方法。它们被翻译成日语。D组：会员实验室使用的分析方法。列出了会员实验室使用的分析方法。这些信息被整理好，放到了一个网站上：<http: //maple-www2.med.hiroshimau.ac.jp>。载有资料的光盘已分发给无法上网的实验室。利用internet开发了一个分析请求系统。当化学家无法在实验室分析一种毒药时，他或她可以通过ml-poison列表向另一个实验室发出分析请求。这是一个将日本法律医学领域和其他相关领域的所有分析实验室通过互联网连接起来的项目。如果这个系统运行良好，我们可以很快知道由于药物或化学危害而中毒的原因。少