Study on health

健康研究

• 批准号: 10557200
• 负责人: HARADA Nobuhiro
• 金额: $ 6.59万
• 依托单位: National Institute of Infections Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557200/
• 关键词: elderly; dental caries; saliva; 唾液; 連鎖球菌; 肺炎

We investigated correlation between health status and health-promoting factors in the oral region. We assumed that health-promoting factors in the oral region would play an important role to prevent a man from infecting serious diseases through respiration and feeding. We performed oral examination of elderly people who keep their own teeth of 20 at the age of 80 (we call them 8020 people), according to WHO oral examination procedures. In detail, composition of oral bacterial flora, saliva constituent, saliva volume, salivary buffering were examined. Blood constituent, diet convention, athletic capacity were studied to clarify their relation with oral health status. Bacterial species studied were Candida albicans, Streptococcus mutans. Streptococcus sobrinus, Streptococcus pneumoniae, Psedomonos aeruginosa, Staphylococcus aureus. Haemophilias oarainfluenzae, etc. Furthermore, we put our attention on antibacterial peptide in saliva, such as defensin and histatin, and did quantitative analysis of these peptides.

我们调查了口腔区域健康状况与健康促进因素之间的相关性。我们假设口腔区域的健康促进因素将在防止男性通过呼吸和进食感染严重疾病方面发挥重要作用。我们根据WHO口腔检查程序，对80岁时保持自己牙齿20岁的老年人(我们称他们为8020人)进行口腔检查。详细检测口腔细菌菌群组成、唾液成分、唾液量、唾液缓冲能力。研究血液成分、饮食习惯、运动能力与口腔健康状况的关系。所研究的细菌种类为白色念珠菌、变形链球菌。远缘链球菌、肺炎链球菌、铜绿假单胞菌、金黄色葡萄球菌。此外，我们还关注了唾液中的抗菌肽，如防御素和组蛋白，并对这些抗菌肽进行了定量分析。

项目成果

Murata, T.: "Periodontitis and serum interleukin-6 levels in the elderly"Jpn J Infect Dis. 54. 69-71 (2001)

Murata, T.：“老年人的牙周炎和血清白细胞介素 6 水平”Jpn J Infect Dis。

ETO A: "Inhibitory effect of a self-derived peptide on glucosytransferase of Streptococcus mutans"J. Biol. Chem.. 274. 15797-15802 (1999)

ETO A：“自源肽对变形链球菌葡萄糖转移酶的抑制作用”J。

Hanada N: "The relationship between oral health status and biological and psychosocial function 〜"Archirey of Gerontology and Geriatrics. 33. 133-140 (2001)

Hanada N：“口腔健康状况与生物和心理社会功能之间的关系〜”Archirey of Gerontology and Geriatrics 33. 133-140 (2001)

Tada A, Hanada N, Tanzawa H.: "The relation between tube feeding and psendonouas aeruginous detection in the oval cavity"A. Biol. Sci. Med. Sci.. 57. 71-72 (2002)

Tada A，Hanada N，Tanzawa H.：“管饲与卵圆腔内假铜绿菌检测之间的关系”A。

H.Takenchi: "New dental drug delivery system for removing mutans streptococci from the oral cavity."Jpn.J.Infect.Dis.. 53. 211-212 (2000)

H.Takenchi：“用于从口腔中去除变形链球菌的新型牙科药物输送系统。”Jpn.J.Infect.Dis.. 53. 211-212 (2000)