ESTABLISHMENT OF FOOD HABITS HELPFUL TO PREVENT LIFE STYLE RELATED DISEASES BY USE OF ANTI-OXIDATIION AND ANTI-STRESS VITAMINS

如今，预防各种与生活方式相关的疾病是大多数中老年日本人非常关心的问题。大多数日本人也知道，饮食习惯实际上控制着他们的营养，因此他们的健康对于减少患上与生活方式有关的疾病的风险非常重要。另一方面，糖尿病是日本最常见和典型的生活方式相关疾病之一，在老年人中非常流行，吸烟也被认为会增加患肺癌的风险，并对包括糖尿病在内的这些疾病的发展产生各种影响。L-抗坏血酸，又称维生素C，是一种必需的水溶性营养素，广泛参与胶原的生物合成、芳香氨基酸的代谢、脂肪代谢、免疫系统的激活和细胞增殖。此外，由于维生素C具有很强的电子供给性，它被广泛用作各种加工食品中的抗氧化剂，也被普遍认为通过其抗氧化和抗应激功能来改善和促进我们的健康。在本研究中，我们试图阐明维生素C的抗氧化功能和抗应激功能的细节，为今后建立饮食习惯，预防各种生活方式相关疾病提出建议。总之，我们进行了各种动物实验，获得了提出建议所需的基本实验数据，并通过对维生素C及其相关化合物的生物学、营养、抗氧化、抗应激功能的大量报道的调查，可以获得足够的信息，为建立有助于通过使用抗氧化和抗应激维生素预防生活方式相关疾病的饮食习惯提供建议。

Nowadays, prevention of various life style related disease is a great concern of most middle or higher aged Japanese people. Most Japanese people also know that food habits which actually control their nutrition and therefore their health is very important to reduce the risk to suffer from life style related diseases. On the other hand, diabetes, one of the most common and typical life style related diseases in Japan, is very popular in elderly people, and smoking is also known to increase the risk of lung cancer and give various effects on the development of these diseases including diabetes. L-ascorbic Acid, which is also called Vitamin C, is an essential water soluble nutrient, and is widely known to be involved in the bio-synthesis of collagen, metabolism of aromatic amino acids, lipid metabolism, activation of immune system and cell multiplication. Furthermore, owing to its strong electron donating property, Vitamin C is widely used as an antioxidant in various processed foods, and also very commonly believed to contribute to the improvement and promotion of our health by its anti-oxidation and anti stress function. In this study, we tried to clarify the details of the anti-oxidation function and anti-stress function of Vitamin C to make a proposal which will be helpful to establish the food habits to prevent various life style related diseases in the future. In short, we made various animal experiments and could obtain basic experimental data necessary to make our proposal, and also by the survey on the many reports on the biological, nutritional, anti-oxidative, anti-stress function of Vitamin C and its related compounds, we could get enough information to make our proposal for the establishment of food habits helpful to prevent life style related diseases by use of anti-oxidation and anti-stress vitamins.