Studies on Stochastic Machine based on Stochastic Resonance and Bio-molecular Machine

基于随机共振和生物分子机的随机机研究

• 批准号: 10558130
• 负责人: MATSUURA Hiroyuki
• 金额: $ 4.54万
• 依托单位: National Graduate Institute for Policy Studies
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10558130/
• 关键词: stochastic resonance; actin myosin system; molecular machine; stochastic machine; Brownian motion; Nyquist Theorem; thermal noise; SN ratio; 閾値; 確率共鳴機械; ナノマシンシステム; 分子機械; 散逸系; 量子ゆらぎ; トンネル効果; 筋肉組織; 分子間力ギア; Stochastic Machine; レーザーピンセット; ゆ

The ultimate goal of this study is to create an energy transformation device (micro actuator) that functions in living bodies. Aiming this, we built a micro actuator and analyzed its motion, energy transformation mechanism in the water. To develop studies on conventional vibrating artificial muscles, we thought of muscle as biomolecular machine. This new model of molecular machine as Actin Myosin System named Stochastic Inclined Rods model (SIRM), whose energy of motion is supplied from random noise and always moves to one direction, has been proposed. SIRM has a simple structure, which is composed of an inclined spring, myosin head, and bundle of rods. In an open system, the myosin head works as a resonator of random noise, which accepts the energy through a resonance. It is shown that the inclined rod and a spherical shape of G-actin are very important elements for a purpose of breaking symmetric vibration of stochastic resonance and generating the one directional motion. Although the potentials of G-actin and the myosin head are completely symmetrical, the structure of the actin myosin system makes it possible to move asymmetry. We have got the SIRM's solution by two method (perturbative methods and numericalones)

本研究的最终目标是创造一种能在活体中发挥作用的能量转换装置（微致动器）。针对这一问题，构建了微致动器，并对其在水中的运动、能量转换机理进行了分析。为了开展常规振动人工肌肉的研究，我们将肌肉视为生物分子机器。提出了一种新的分子机器模型，即肌动蛋白-肌球蛋白系统的随机斜杆模型（SIRM），它的运动能量由随机噪声提供，并且总是向一个方向运动。SIRM结构简单，由倾斜弹簧、肌凝蛋白头和一束棒组成。在一个开放的系统中，肌凝蛋白头部作为随机噪声的谐振器，通过共振接受能量。结果表明，g -肌动蛋白的斜杆和球形结构是打破随机共振对称振动并产生单向运动的重要因素。虽然g -肌动蛋白和肌凝蛋白头的电位是完全对称的，但肌动蛋白-肌凝蛋白系统的结构使得不对称运动成为可能。我们用两种方法（微扰法和数值法）得到了SIRM的解。

项目成果

中野正博: "Nuclear Schwinger-Dyson Methodの新展開"素粒子研究. 102(1). 68-72 (2000)

Masahiro Nakano：“核施温格-戴森方法的新发展”《基本粒子研究》102(1) (2000)。

Matsuura H, Nakano M: "Stochastic Dynamics of Molecular Machine, It's nanomachine which is based on Nyquist Theory"Proceeding of the 1999 International Symposium on Micromechatronics and Human science (MHS'99), IEEE. ISBN 0-7803-5790-6. 51-58 (1999)

Matsuura H、Nakano M：“分子机器的随机动力学，它是基于奈奎斯特理论的纳米机器”1999 年微机电一体化和人类科学国际研讨会 (MHS99) 论文集，IEEE。

Matsuura H, Nakano M: "Stochastic dynamics of Molecular Machine, Japanese Association for Mathematical Biology"JAMB Nesletter. 29. 10 (1999)

Matsuura H，Nakano M：“分子机器的随机动力学，日本数学生物学协会”JAMB Nesletter。

岩崎清隆,松浦弘幸,井街宏,中野正博 他: "X線回折実験によるJellyfish弁の弁葉破壊挙動の解明を目指した基礎的検討"第10回バイオエンジンアリング講演論文集. 97(2). 181-182 (1998)

Kiyotaka Iwasaki、Hiroyuki Matsuura、Hiroshi Imachi、Masahiro Nakano 等人：“旨在利用 X 射线衍射实验阐明水母瓣膜小叶破坏行为的基础研究”第十届生物工程会议记录 97(2) .181-182。 (1998)

Matsuura H,Nakano M,Liu LG.: "A Sliding Model of Acten Myosin System based on Nyquist Theorem"Proc.of IEEE_EMBS Asia-Pacific Conference on Biomedical Engineering. ISBN7-5062-4828-X. 377-378 (2000)

Matsuura H,Nakano M,Liu LG.：“基于奈奎斯特定理的肌球蛋白系统滑动模型”IEEE_EMBS 亚太生物医学工程会议论文集。