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Studies establishment of high rink group for bile duct cancer

胆管癌高溜冰组建立的研究

基本信息

批准号：
11470257
负责人：
MATSUMOTO Yoshiro
金额：
$ 8.77万
依托单位：
University of Yamanashi, Faculty of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

Pancreaticobiliary maljunction (PBM), a congenital anomaly defined as the union of the pancreatic and biliary ducts located outside the duodenal wall, is a recently designated disease entity, and is frequently associated with congenital choledochal cyst (CCBD), which is thought to be different from PBM in embryonic etiology, and variegated clinical features, such as digestive diseases appear in patients with PBM and CCBD.From an analysis of 250 PBM patients (169 with benign hepatobiliary and pancreatic disease and 81 with malignancy) the pathophysiologic and clinical aspects and biliary carcinogenesis in PBM patients were reviewed. PBM is thought to develop as a misarrangement of the embryonic connections in the pancreaticobiliary ductal system, in which the terminal bile duct is joined with one of the ducts of the ventral pancreas.The clinical aspects are intermittent abdominal pain, relapsing acute pancreatitis, jaundice, cholangitis and gallbladder cancer. In patients with PBM and C … More CBD, primary bile duct stones, acute cholangitis and bile duct cancer are considered to result from cholestasis, regurgitation of pancreatic juice, and reciprocal reflux of bile and pancreatic juice. Moreover, the mixture of bile and pancreatic juice due to reciprocal reflux very likely plays an important role in biliary carcinogenesis.In PBM patients, an elevation of cellular proliferation activity in the gallbladder epithelia, was reported. A number of oncogenes and tumor suppressor genes have been identified and implicated in carcinogenesis, and, in particular, the K-ras oncogene and the p53 suppressor gene are the best-studied genes in gallbladder carcinogenesis with PBM. K-ras mutations were reported that did not appear essential for hyperplasia, but may be an early event in carcinogenesis. The p53 mutations were also reported to be involved in carcinogenesis in the biliary epithelium in PBM patients.Key Words: misarrangement of the embryonic connections in pacreaticobiliary ductal system, gallbladder cancer, bile duct cancer, relapsing acute pancreatitis, obstructive jaundice. Less

胰胆管合流异常（PBM）是一种先天性异常，定义为胰管和胆管位于十二指肠壁外的结合，是最近被命名的疾病实体，并且经常与先天性胆总管囊肿（CCBD）相关，其被认为在胚胎病因学上不同于PBM，并且临床特征多样，对250例PBM患者的临床资料进行分析，（169例良性肝胆胰疾病，81例恶性肿瘤）本文就PBM的病理生理、临床及胆管癌的发生进行综述。PBM被认为是胚胎期胰胆管系统连接的错误排列，其中末端胆管与腹侧胰腺的一个管道连接。临床表现为间歇性腹痛、复发性急性胰腺炎、黄疸、胆管炎和胆囊癌。在PBM和C患者中 ...更多信息 CBD、原发性胆管结石、急性胆管炎和胆管癌被认为是由胆汁淤积、胰液反流以及胆汁和胰液的相互反流引起的。此外，胆汁和胰液的混合物，由于反流很可能在胆管癌的发生中起着重要的作用。在PBM患者，在胆囊上皮细胞增殖活性的升高，据报道。许多癌基因和肿瘤抑制基因已被鉴定并与癌发生有关，特别是K-ras癌基因和p53抑制基因是PBM胆囊癌发生中研究最多的基因。据报道，K-ras突变似乎不是增生所必需的，但可能是癌变的早期事件。p53突变也被报道参与PBM患者胆管上皮的癌变. Keywords：pacreaticobiliary ductal system，gallbladder cancer，bile duct cancer，recursing acute pancreatitis，obstructive juice.少