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Studies on the biological responses to mechanical stress on jaw bone and periodontium, and their clinical applications.

颌骨和牙周组织对机械应力的生物学反应及其临床应用的研究。

基本信息

批准号：
17592130
负责人：
MATSUMOTO Yoshiro
金额：
$ 2.05万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17592130/
关键词：
jaw bone periodontium mechanical stress occlusal force tooth transplantation alveolar bone

项目摘要

In order to investigate the biological responses to mechanical stress on jaw bone and periodontium, we aimed to apply the orthodontic force to the teeth in order to enlarge the space of periodontal ligaments (PDL), which may ease extraction and minimize the damage of PDL before transplantation. The orthodontic force was applied to the right upper molars for the experimental group, and after 7days, upper second molars were replanted or extracted, where replanted animals were then sacrificed after 14 days and those extracted teeth were examined for the attached PDL and exposed root surface. The application of orthodontic force for 7 days increased the PDL space and also the width of the alveolar socket, which resulted in the rich attached PDL to the root surface of the extracted teeth. And enhanced root resorption that may have been coincided with the disruption of the PDL was detected in the root of the control group without pre-application of orthodontic force at the 14 days after repl … More antation. These results suggested that the pre-application of orthodontic force to the donor teeth increased the PDL width and ease the extraction, which may inhibit the root resorption after replantation. The influences of occlusal loading on the alveolar bone remodeling and the distribution of vasoactive intestinal peptide (VIP)- and calcitonin generelated peptide (CGRP)-immunoreactive (IR) fibers were investigated after tooth replantation in rats. At day 5, occlusal loading induced a significant increase in osteoclast number and osteoblast surface compared to those in the non-occluded group. VIP-IR fibers were observed beside osteoblastic layers and their distribution was significantly enhanced at day 5 in the occluded group, compared to the non-occluded group. Although there was immunoreactivity for CGRP in the periodontal ligament and alveolar bone apically, CGRP-IR fibers were not detected above the furcation. These results suggest that, after tooth replantation in rats, occlusal loading induced an increase in osteoclast and osteoblast formation, and that VIP might play a functional role in osteoblasts. Less

为了研究颌骨和牙周组织对机械应力的生物反应，我们的目的是在牙齿上施加正畸力，以扩大牙周韧带(PDL)的间隙，从而使牙周韧带在移植前易于拔除，并将其损伤降至最低。实验组对右侧上颌磨牙施加正畸力，7d后再植或拔除上颌第二磨牙，14d后处死动物，观察拔除后牙的牙周膜附着情况和根面裸露情况。正畸力作用7d后，牙周膜间隙增大，牙槽窝宽度增加，牙根表面附着牙周膜丰富。在REPEL…后14天，未施加正畸力的对照组牙根中检测到可能与牙周韧带断裂相一致的牙根吸收增强更多的移植。这些结果提示，对供牙施加正畸力，可增加牙周韧带宽度，减轻拔牙困难，从而抑制再植后牙根的吸收。观察咬合负荷对大鼠牙再植后牙槽骨改建及血管活性肠肽(VIP)和降钙素基因相关肽(CGRP)免疫反应纤维分布的影响。在第5天，咬合负荷诱导破骨细胞数量和成骨细胞表面与非咬合组相比显著增加。成骨细胞层旁可见VIP-IR纤维，与非闭塞组相比，闭塞组第5天时VIP-IR纤维的分布明显增强。虽然CGRP在牙周膜和牙槽骨中有免疫反应，但在分叉部以上未检测到CGRP-IR纤维。这些结果表明，大鼠牙齿再植后，咬合负荷诱导破骨细胞和成骨细胞的形成增加，VIP可能在成骨细胞中发挥作用。较少