Factors affecting human placental transfer of anesthesia-related drugs.

影响麻醉相关药物人胎盘转移的因素。

基本信息

  • 批准号:
    11470330
  • 负责人:
  • 金额:
    $ 3.78万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1999
  • 资助国家:
    日本
  • 起止时间:
    1999 至 2001
  • 项目状态:
    已结题

项目摘要

Placental transfer of porpofol in human dually per fused cotyledon in vitro.We investigated the effects of uterine and umbilical blood flow and albumin concentration (protein binding) on the placental transfer ofpropofol by using the dually per fused human placental cityledon(single pass mode). Placental transfer was evaluated on the basis ofplacental clearaces at various flow rates or albumin concentrations of maternal and fetal perfusates. Antipyrine was added to the maternal perfusate as a reference. As results, (l) With increasing albumin concentrations of the fetal perfusate at constant maternal albumin level, propofol concentrations of fetal perfusate and its clearance were increased while both unbound propofol concentration and antipyrine clearance were unchaged. (2) With increasing albumin concentrations of maternal perfusate, propofol concentration of fetal outflow and placental clearance were decreased. (3) With increasing maternal blood flow, the propofol concentration of fetal out flow was increased while both clearance ofpropofol and antipyrine were increased (clearance ratio was constant). (4) With increasing fetal blood flow, the propofol concentration of fetal out flow was unchanged while clearance of propofol was flow-dependency increased but clearance of antipyrine showed ceiling.(5) Propofol significantly partitioned to placental tissues and the placenta would act as a condenser.In summary, our model could exactly denote the placental transfer of drug using the parameter of clearance while traditional determination of maternal and fetal blood concentration (F/M ratio) was extremely influenced with uterine blood flow, umbilival blood flow, and protein binding in maternal and umbilical blood
胎泊酚在人双子叶离体胎盘移植中的应用。本研究采用双融合人胎盘腔(单通道模式)研究子宫和脐血流量及白蛋白浓度(蛋白结合)对异丙酚胎盘转移的影响。根据不同流速或母体和胎儿灌注物白蛋白浓度的胎盘清除率来评估胎盘转移。在母体灌注液中加入安替比林作为对照。结果表明:(1)在母体白蛋白水平不变的情况下,随着胎儿灌注液中白蛋白浓度的增加,胎儿灌注液中异丙酚浓度及其清除率增加,而未结合的异丙酚浓度和安替比林清除率不变。(2)随着母体灌注液白蛋白浓度的升高,胎儿流出物异丙酚浓度和胎盘清除率降低。(3)随着母体血流量的增加,胎儿流出液中丙泊酚浓度升高,丙泊酚和安替比林的清除率均升高(清除率不变)。(4)随着胎儿血流量的增加,胎儿流出液中丙泊酚浓度不变,丙泊酚清除率呈流量依赖性增加,而安替比林清除率呈上限。(5)异丙酚对胎盘组织有明显的分割作用,胎盘起凝血剂的作用。综上所述,我们的模型使用清除率参数能够准确表征药物的胎盘转移,而传统的母胎血浓度测定(F/M比)受子宫血流量、脐带血流量以及母脐血蛋白结合的影响极大

项目成果

期刊论文数量(32)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
He YL,Tsujimoto S,Tanimoto R,Okutani R,Murakawa K,Tashiro C.: "Effects of protein binding on the placental transfer of propofol in the human dually perfised cotyledon in vitro."Br J Anaesth. 85(2). 281-286 (2000)
He YL,Tsujimoto S,Tanimoto R,Okutani R,Murakawa K,Tashiro C.:“蛋白质结合对体外人双穿孔子叶中异丙酚胎盘转移的影响”Br J Anaesth。
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
He YL, Seno H, SasaKi K, Tashiro C: "The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfised cotyledon in vitro"Anesth Analg. 94(4)(In press). (2002)
He YL,Seno H,SasaKi K,Tashiro C:“母体白蛋白浓度对体外人双穿孔子叶中异丙酚胎盘转移的影响”Anesth Analg。
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    0
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He YL, Seno H, Sasaki K, Tashiro C: "The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion."Anesth Analg. 93(1). 151-156 (2001)
He YL、Seno H、Sasaki K、Tashiro C:“体外灌注过程中子宫和脐血流动对异丙酚穿过人胎盘转移的影响。”Anesth Analg。
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
Seno H, He YL, Tashiro C, et al.: "Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various rat tissues"J Anesthesia. 16(1). 87-89 (2002)
Seno H,He YL,Tashiro C,等:“人和大鼠血浆和各种大鼠组织中异丙酚的简单高效液相色谱测定”J Anesthesia。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
He YL, Seno H, Tsujimoto S, Tashiro C.: "The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion"Anesth Analg. 93(1). 151-156 (2001)
He YL、Seno H、Tsujimoto S、Tashiro C.:“体外灌注过程中子宫和脐血流动对异丙酚穿过人胎盘转移的影响”Anesth Analg。
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    0
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TASHIRO Chikara其他文献

TASHIRO Chikara的其他文献

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{{ truncateString('TASHIRO Chikara', 18)}}的其他基金

Factors affecting human placental transfer of anesthesia-related drugs.
影响麻醉相关药物人胎盘转移的因素。
  • 批准号:
    14370498
  • 财政年份:
    2002
  • 资助金额:
    $ 3.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of factors affecting placental transfer of anesthetic drugs and umbilical circulation with the delivered human-placenta perfusion model.
通过人胎盘灌注模型分析影响麻醉药物胎盘转移和脐循环的因素。
  • 批准号:
    07457363
  • 财政年份:
    1995
  • 资助金额:
    $ 3.78万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Electroretinogram as a Monitor of Depth and Brain Ischemia, and as a model to study mechanisms of anesthesia.
视网膜电图作为深度和脑缺血的监测器,并作为研究麻醉机制的模型。
  • 批准号:
    60570720
  • 财政年份:
    1985
  • 资助金额:
    $ 3.78万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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用于胎盘灌注和氧输送体内评估的 MR 成像方法的开发和验证
  • 批准号:
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Development and validation of MR imaging methods for in vivo assessment of placental perfusion and oxygenation
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  • 财政年份:
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Development and validation of MR imaging methods for in vivo assessment of placental perfusion and oxygenation
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  • 财政年份:
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用于研究母胎生物学的离体胎盘灌注系统
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  • 财政年份:
    2009
  • 资助金额:
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An ex-vivo placental perfusion system to study materno-fetal biology
用于研究母胎生物学的离体胎盘灌注系统
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    2009
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